Bayer Aktiengesellschaft

The Broad Institute, Inc.

Bayer Pharma Aktiengesellschaft

Other

Chris A Lemke

Ulrich Klar

Christopher G Nasveschuk

Michael H Serrano-Wu

Kai Thede

Joachim Kuhnke

Philipp Buchgraber

Steven James Ferrara

Nicolas Werbeck

Clara Christ

Sarah Anna Liesa Johannes

David A McKinney

Guo Wei

Patrick Ryan McCarren

Mark A Fitzgerald

Laura Furst

Anne Mengel

Amaury Ernesto Fernandez-Montalvan

Stefan Kaulfuss

Ulrike Rauh

Katrin Nowak-Reppel

Ursula Mönning

Ursula Moenning

Rebecca Ann Harvey

Sven Wittrock

Ulrike Sack

Thomas Pesnot

Daniel Payne

Craig Wilson

Philip Lienau

Knut Eis

Arne Scholz

Manfred Moewes

Amaury Fernandez-Montalvan

Jérémie Xavier Mortier

The present invention relates to macrocyclic indole derivatives of general formula (I): in which R, R, R, R, R, R, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

Macrocyclic fluorine substituted indole derivatives

The present invention relates to substituted macrocyclic indole derivatives of general formula (I): in which R, R, R, R, R, R, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

Substituted macrocyclic indole derivatives

Macrocyclic chlorine substituted indole derivatives

Macrocyclic indole derivatives

The present invention relates to macrocyclic indole derivatives of general formula (I): in which R, R, R, R, R, R, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical 2019 compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

A chlorine generator cell () contains components that require physical isolation between the anode compartment (), cathode compartment (), and outside environment. The cell () also contains a membrane () that provides selective electrical conductivity between the anode compartment () and cathode compartment (). The cell () consists of a series of pipe fittings that allow access to the interior of cell () for placement of water and salt to generate chlorine. The anode stem () and cathode stem () located outside of cell () are connected to a power supply (). Power supply () may be further connected to a power controller () that allows for adjustment of the energy output of power supply () to the optimum energy level, thus the desired chlorine output. This invention provides a chlorine generator that is portable, yet is allows for expanded size with additional pipe fittings as needed. Furthermore, this invention allows multiple to infinite chlorine output levels with a single cell ().

Chlorine generator

A chlor-alkali cell (10) contains components that require physical isolation between the anode compartment (20), cathode compartment (30), and outside environment. The cell (10) also contains a membrane (50) that provides selective electrical conductivity between the anode compartment (20) and cathode compartment (30). The cell compression system consists of a single cell compression sleeve (40) at houses the components of the chlor-alkali cell (10). The cell compression sleeve (40) uniformly distributes and maintains a compressive force along an anode seal (60) and cathode seal (61) membrane (50) which is located at the junction of the anode compartment (20) and cathode compartment (30).

Chlor alkali cells method and cell compression system

The density of a caustic solution is reduced by automatically adding water to the caustic solution when the specific gravity of the caustic solution is unacceptably high. The mechanism consists of a flow control valve that is controlled by an switch that monitors the position of a hydrometer. The switch is activated when the density of the caustic solution rises to unacceptable levels, causing the hydrometer to rise and activate the switch. The switch controls a valve that opens and allows water to enter the caustic solution reservoir, thereby diluting the caustic solution. When sufficient water has been added to the caustic, the hydrometer drops and the switch is deactivated, thereby closing the valve that allows water to enter the caustic solution reservoir. Excess caustic solution leaves the reservoir through an overflow on the reservoir.

Fluidic density control for chlor alkali cells

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Fresno, CA, United States of America

Chris A Lemke