Il Yang Pharmaceutical Company, Ltd.

Dong-A Pharm. Co., Ltd.

Choon W Lee

Chun Hee Chung

Kwon Haeng Lee

Hoon Chung

Soon Hoe Kim

Youngmoon Choi

Hyun T Shin

Joon W Kim

Moohi Y Kim

Moon H Son

This invention relates to a strain, Ganoderma lucidum IY 009 which produces a proteoglycan G 009 possessed of antitumoral and immunostimulating effects, separated from the said cultured strain, containing: .beta.-glucose, .alpha.-glucose, galactose, .alpha.-mannose and fructose as saccharide components, and glycine, alanine, histidine, arginine, valine, aspartic acid, threonine, isoleucine, serine, leucine, glutamic acid, tyrocine, proline, phenylalanine and methionine as protein components. The Ganoderma lucidum IY 009 is deposited under accession number KCCM 10045.

Ganoderma lucidum KCCM 10045 which produces proteoglycan (G009) having

Proteoglycan(G009) effective in enhancing antitumor immunity

A benzoxazine or benzothiazine derivative of the formula (A), ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are the same or different and represent a hydrogen atom or a C.sub.1-4 alkyl group; or R.sub.1 and R.sub.2 can be joined together along with the imidazole ring to form a benzimidazole; X and Y are the same or different and represent an oxygen or sulfur atom; or a pharmaceutically acceptable salt thereof, exhibits an excellent inotropic effect and can be used as a cardiac stimulant.

Imidazole substituted benzoxazine or benzothiazine derivatives

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Seoul, South Korea

Choon W Lee