Sungkyunkwan University

Korea Research Institute of Bioscience and Biotechnology

Sg Corporation

Choon Gon Jang

Sang Ho Choi

Sang-Woo Lee

Sei-Ryang Oh

Hyung Won Ryu

Wan Yi Li

Hang Jin

Seung Hwan Kwon

The present invention relates to a composition which is for preventing or treating caffeine abuse and includes evodiamine orextract. More specifically, the present invention relates to a pharmaceutical composition which has an effect of preventing or alleviating somnipathy and central nervous system excitation caused by caffeine. In addition, the present invention relates to a caffeine abuse treatment method and a health functional food composition includingextract or evodiamine.

Composition for preventing or treating diseases caused by caffeine abuse including Evodia officinalis extract or evodiamine as active ingredient

The present invention relates to a pharmaceutical composition and a food composition containingHook. extract or a fraction thereof as an active ingredient for preventing, treating or ameliorating neuroinflammation or neuro-degenerative diseases. TheHook. extract or a fraction thereof according to the present invention is derived from a natural product which has been in use as a natural medicinal ingredient, and as such, has no side effects and inhibits expression of NO, PGE, iNOS and/or COX-2 genes or protein, which are factors associated with inflammation, and is additionally superbly effective for increasing and improving memory and the ability to learn, and thus can be beneficially used to prevent or treat neuroinflammation or neuro-degenerative diseases.

Method for treating neuroinflammation with a pharmaceutical composition containinghook. extract or fraction thereof as active ingredient

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Suwon-si, South Korea

Choon Gon Jang