Korea Research Institute of Chemical Technology

Novartis Ag

Katholieke Universiteit Leuven

Chonsaeng Kim

Hae Soo Kim

Daniel J Poon

Keith Bruce Pfister

Johan Neyts

Soo Bong Han

Jin Soo Shin

Chong-Kyo Lee

Young-Sik Jung

Yashwardhan R Malpani

Prashant Chakrasali

Bum Tae Kim

Seong Jun Kim

Sang-Ho Lee

Bishyajit Kumar Biswas

Dae Gyun Ahn

Kyun Do Kim

Young Chan Kwon

Keunbon Ku

In Su Hwang

The invention provides compounds of Formula (I):

Antiviral 1,3-di-oxo-indene compounds

The present invention relates to a transmembrane domain derived from human LRRC24 protein. More specifically, the present invention relates to a transmembrane domain derived from the human LRRC24 protein (LRRC24P transmembrane domain) or a cell-penetrating peptide, and an intracellular delivery system comprising same. The transmembrane domain derived from the human LRRC24 protein of the present invention can be used to deliver cargo materials such as compounds, biomolecules, and various polymer materials into cells. Since the LRRC24P transmembrane domain of the present invention exhibits higher cell penetration efficiency compared to conventional cell-penetrating peptides and is derived from human proteins, thus avoiding side effects and immune responses caused by peptides derived from foreign proteins, it can be usefully used as an effective intracellular delivery method for compounds, biomolecules, and various polymer materials applied to the human body.

Transmembrane domain derived from human LRRC24 protein

This disclosure provides compounds of Formula (I)

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Daejeon, South Korea

Chonsaeng Kim