The General Hospital Corporation

Chongzhao Ran

Anna V Moore

Jian Yang

Anna Moore

Xueli Zhang

Anna-Liisa Brownell

Provided herein are curcumin analogues that are able to interact with amyloid beta (Aβ) and to attenuate the copper-induced crosslinking of Aβ. Also provided herein are methods of using the compounds as imaging agents of amyloid beta and for the treatment of diseases associated with amyloid beta. Methods of preparing unlabeled and radiolabeled compounds useful for interacting with amyloid beta and pharmaceutical compositions are also provided.

Half-curcuminoids as amyloid-β PET imaging agents

Half-curcuminoids as amyloid-beta pet imaging agents

Provided herein are curcumin analogues that are able to interact with amyloid beta (A&#x3b2;) and to attenuate the copper-induced crosslinking of A&#x3b2;. Also provided herein are methods of using the compounds as imaging agents of amyloid beta and for the treatment of diseases associated with amyloid beta. Methods of preparing unlabeled and radiolabeled compounds useful for interacting with amyloid beta and pharmaceutical compositions are also provided.

Half-curcuminoids as amyloid-beta PET imaging agents

The present invention provides curcumin-derived near infrared (NIR) imaging probes. Upon interacting with amyloid &#x3b2; aggregates, these probes undergo a range of changes, qualifying them as 'smart' probes. The inventors have demonstrated that probes of the invention have the capacity to monitor the progression of Alzheimer's disease in an in vivo animal model. In addition, the present invention encompasses probes useful as PET imaging agents, MRI imaging agents and multimodal imaging agents, as well as related methods of detecting and imaging amyloid &#x3b2; aggregates and plaques.

Curcumin derivatives for amyloid-&#x3b2; plaque imaging

Methods and compositions for imaging Brown adipose tissue (BAT) in living mammals, e.g., humans.

Imaging brown adipose tissue with curcumin derivatives

Provided herein are curcumin analogues that are able to interact with amyloid &#x3b2; (A&#x3b2;) and to attenuate the copper-induced crosslinking of A&#x3b2;. Also provided herein are methods of using the compounds in the treatment of Alzheimer's Disease or a related disorder.

Curcumin analogs

The present invention provides methods of detecting soluble amyloid &#x3b2; using curcumin-derived near infrared (NIR) imaging probes. Upon interacting with soluble amyloid &#x3b2;, these probes undergo a range of changes, qualifying them as 'smart' probes. In addition, the invention provides methods of detecting soluble amyloid &#x3b2; by positron emission tomography (PET), magnetic resonance imaging (MRI) and multimodal imaging based on the curcumin-derived NIR imaging probes and derivatives thereof.

Growing community of inventors

Winchester, MA, United States of America

Chongzhao Ran