University of Massachusetts

Purdue Pharma L.p.

Euro-celtique S.a.

Pharmacopeia Inc.

Chongwu Zhang

Jusong Xia

Louis A Carpino

Calin Dan Sferdean

Donald Kyle

Qun Sun

Laykea Tafesse

Xiaoming Zhou

Vidyadhar Madhav Paradkar

Ray Anthony James

Michelle Lee Morris

Rui Zhang

Ruiyan Liu

Michael J Ohlmeyer

Marc Brescia

Jinqi Liu

James Robert Merritt

The present invention is directed to compounds of the formula: or salts thereof or N-oxides and their use in peptide synthesis.

Coupling agents for peptide synthesis

Compounds of the formula are disclosed. The compounds are CCR1 antagonists which are useful for the treatment and prevention of inflammatory and autoimmune diseases. Other embodiments are also disclosed.

Ortho pyrrolidine, benzyl-substituted heterocycle CCR1 antagonists for autoimmune diseases and inflammation

The present invention is directed to compounds of the formula (I) and (II) or salts thereof or N-oxides and their use in peptide synthesis. 

A compound of formula: wherein A, Ar, R, R, and m are disclosed herein, or a pharmaceutically acceptable salt thereof (a 'Cyanoiminopiperazine Compound'), compositions comprising an effective amount of a Cyanoiminopiperazine Compound, and methods for treating or preventing pain, urinary incontinence, an ulcer, inflammatory-bowel disease, irritable-bowel syndrome, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia or depression in an animal comprising administering to an animal in need thereof an effective amount of a Cyanoiminopiperazine Compound are disclosed.

Therapeutic agents useful for treating pain

Growing community of inventors

Dayton, NJ, United States of America

Chongwu Zhang