Harvard College

Chong Si

Andrew G Myers

Matthew D Shair

Alec Nathanson Flyer

Hong Myung Lee

Cristina Montserrat Nieto-Oberhuber

The present invention relates to analogs of cortistatin A, J, K, and L, having the general formula: and salts thereof, wherein R, R, R, R, n, and m are as defined herein; processes for preparing such compounds and intermediates thereto; pharmaceutical compositions comprising such compounds; methods for treating a proliferative disease; methods for treating a disease associated with aberrant angiogenesis; methods for inhibiting angiogenesis; and processes for preparing cortistatin A, J, K, and L, and analogs thereof.

Cortistatin analogues and syntheses thereof

The present invention relates to analogs of cortistatin A, J, K, and L, having the general formula: I and salts thereof, wherein R, R, R, R, n, and m are as defined herein; processes for preparing such compounds and intermediates thereto; pharmaceutical compositions comprising such compounds; methods for treating a proliferative disease; methods for treating a disease associated with aberrant angiogenesis; methods for inhibiting angiogenesis; and processes for preparing cortistatin A, J, K, and L, and analogs thereof. 

Growing community of inventors

Allston, MA, United States of America

Chong Si