Bristol-myers Squibb Compnay

E. R. Squibb Sons, Inc.

Other

Bristol-myers Squibb

Chong-qing Sun

Jeffrey A Robl

Gregory S Bisacchi

Eric M Gordon

Robert Zahler

Lawrence G Hamann

Joseph Anthony Tino

Joel C Barrish

David John Augeri

Yingzhi Bi

Ligaya Simpkins

Alexandra Holubec

Gregory D Vite

Yan-Ting Huang

Donald S Karanewsky

Ashvinikumar V Gavai

Dharmpal S Dodd

James Clifford Sutton

Tammy C Wang

James J Li

Philip Michael Sher

William N Washburn

Denis E Ryono

Bang-Chi Chen

Samuel Gerritz

Peter T Cheng

Kathleen M Poss

There are provided compounds according to formula I wherein the substitutents are as described herein. Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia. Also provided are pharmaceutical compositions containing such compounds and processes for preparing some of the compounds of the invention. Other embodiments are also disclosed.

Bicyclic modulators of androgen receptor function

The invention provides compounds according to formula I  Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia. Also provided are pharmaceutical compositions containing such compounds and processes for preparing some of the compounds of the invention.

HMG-CoA reductase inhibitors and method

Compounds having the following formula I, and pharmaceutically acceptable salts thereof, including dual inhibitors of ACE and NEP and selective ACE inhibitors:

Processes and intermediates for preparing benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP

Compounds having the following formula I, and pharmaceutically acceptable salts thereof, including dual inhibitors of ACE and NEP and selective ACE inhibitors: ##STR1## wherein: Y.sup.1 and Y.sup.2 are each independently hydrogen, alkyl, aryl, halogen, or alkoxy;

Benzo-fused azepinone and piperidinone compounds useful in the

Novel aminediol compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds in inhibiting retroviral protease, particularly useful in the treatment and/or prevention of HIV infection (AIDS).

Method of inhibiting protease

Compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof. These compounds are beta three adrenergic receptor agonists and are useful, therefore for example, in the treatment of diabetes, obesity and gastrointestinal diseases.

Catecholamine surrogates useful as .beta..sub.3 agonists

Compounds of the formula ##STR1## wherein A is ##STR2## are dual inhibitors of NEP and ACE. Compounds wherein A is ##STR3## are selective ACE inhibitors.

Thiazolo benzazepine containing dual action inhibitors

Aminediol protease inhibitors

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East Windsor, NJ, United States of America

Chong-qing Sun