Dong-a Pharm. Co., Ltd.

Dong-a St Co., Ltd.

Dong-a Pharmaceuticals Co. Ltd.

Chong Hwan Cho

Tae Ho Lee

Jae Keol Rhee

Weon Bin Im

Sung Hak Choi

Soon Hoe Kim

Mi Rim Jin

Mi Won Son

Sang Jin Choi

Moo Hi Yoo

Nam Joon Baek

Jin Pub Son

Tao Ho Lee

The present invention relates to novel derivatives of oxazolidinone, a method thereof and pharmaceutical compositions comprising the derivatives for use in an antibiotic. The oxazolidinone derivatives of the present invention show inhibitory activity against a broad spectrum of bacteria and lower toxicity. The prodrugs, prepared by reacting the compound having hydroxyl group with amino acid or phosphate, have an excellent efficiency on solubility thereof against water. Further, the derivatives of the present invention may exert potent antibacterial activity versus various human and animal pathogens, including Gram-positive bacteria such asand, anaerobic microorganisms such asand Clostridia, and acid-resistant microorganisms such asand. Accordingly, the compositions comprising the oxazolidinone are used in an antibiotic.

Oxazolidinone derivatives

The present invention relates to herbal extracts ofSemen,Tuber,Seed, andSemen, and a composition containing the same for treating and preventing gastrointestinal motility disorder. The extracts of the present invention have a remarkable effect of promoting gastrointestinal motility through HTreceptor antagonism and/or HTreceptor antagonism.

Extract of herbal and composition containing the same

The present invention relates to novel derivatives of oxazolidinone, a method thereof and pharmaceutical compositions comprising the derivatives for use in an antibiotic. The oxazolidinone derivatives of the present invention show inhibitory activity against a broad spectrum of bacteria and lower toxicity. The prodrugs, prepared by reacting the compound having hydroxyl group with amino acid or phosphate, have an excellent efficiency on solubility thereof against water. Further, the derivatives of the present invention may exert potent antibacterial activity versus various human and animal pathogens, including Gram-positive bacteria such as, Staphylococci, Enterococci and Streptococci anaerobic microorganisms such asand Clostridia, and acid-resistant microorganisms such asand. Accordingly, the compositions comprising the oxazolidinone are used in an antibiotic.

The present invention relates to novel derivatives of oxazolidinone, a method thereof and pharmaceutical compositions comprising the derivatives for use in an antibiotic. The oxazolidinone derivatives of the present invention show inhibitory activity against a broad spectrum of bacteria and lower toxicity. The prodrugs, prepared by reacting the compound having hydroxyl group with amino acid or phosphate, have an excellent efficiency on solubility thereof against water. Further, the derivatives of the present invention may exert potent antibacterial activity versus various human and animal pathogens, including Gram-positive bacteria such as Staphylococi, Enterococci and Streptococi, anaerobic microorganisms such asand Clostridia, and acid-resistant microorganisms such asand. Accordingly, the compositions comprising the oxazolidinone are used in an antibiotic.

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Yongin-si, South Korea

Chong Hwan Cho