Massachusetts Institute of Technology

Malaysian Palm Oil Board

Alko Group Ltd.

Other

Rohm and Haas Company

The Government of Malaysia

ChoKyun Rha

Anthony J Sinskey

Spiros Jamas

Ravigadevi Sambanthamurthi

Yew Ai Tan

Maritta Timonen

Mohd Basri Wahid

Kalyana Sundram P Manickam

Martti Sakari Vaara

Timo Ilmari Vaara

Tarja Lahtinen

Marja K Turunen

Lindsey Bagley

Michael Lindley

Sarah Bosdet

Sambandan Tg

Pasawadee Pradipasena

Tg Sambandan

TetsuHisa Nakamura

Dolores Rodriguez-Sanchez

Kristi D Snell

Sang Jun Sim

T G Sambandan

Donald D Easson, Jr

Elizabeth M Robinson

Joharl Mohammed Saad

Robert P Weinberg

Chan W Kim

Azizol Abdul Kadir

Scott A Hogan

Norhaniza Aminudim

Donald D Easson Jr

T J Sambandan

J Sinskey Anthony

Tan Yew Ai Ai

Present invention discloses an oil palm composition for use in prevention or treatment of Alzheimer's disease. The composition is useful in impeding formation of neurotoxic peptide. Present invention can be used in preparation of a medicament in a therapeutic effective amount for prevention or treatment of Alzheimer's disease and diseases related thereto.

Protective effects of oil palm composition on Alzheimer's disease

A composition comprising caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, said caffeoylshikimic acids and their derivatives extracted from any part of oil palm including but not confined to the vegetation liquor of palm oil milling and palm oil mill effluent, and a method for use in the preparation of a composition containing caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, said caffeoylshikimic acids and their derivatives. The method includes the steps of pre-concentrating an extract containing the caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, caffeoylshikimic acids and their derivatives and isolating the caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, said caffeoylshikimic acids and their derivatives from said extract by liquid chromatography, wherein the elution activity of said caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, with the caffeoylshikimic acids and their derivatives varying depending on the stationary phase and the composition of the mobile phase.

Composition comprising caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid and their derivatives and method of preparation thereof

The present invention provides compositions and method for production of shikimic acid based on extracts obtained from oil palm-based materials, and more particularly oil palm-based waste materials and by-products. The method includes purifying shikimic acid from extracts comprising oil palm phenolics (OPP).

Compositions comprising shikimic acid obtained from oil palm-based materials

A composition comprising caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, caffeoylshikimic acids and their derivatives extracted from any part of oil palm including but not confined to the vegetation liquor of palm oil milling and palm oil mill effluent, and a method for use in the preparation of a composition containing caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, caffeoylshikimic acids and their derivatives. The method includes the steps of pre-concentrating an extract containing the caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, caffeoylshikimic acids and their derivatives and isolating said caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, caffeoylshikimic acids and their derivatives from said extract by liquid chromatography, wherein the elution activity of said caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, caffeoylshikimic acids and their derivatives vary depending on the stationary phase and the composition of the mobile phase.

The present invention provides compositions and method for production of shikimic acid based on extracts obtained from oil palm-based materials, and more particularly oil palm based waste materials and by-products. The method includes purifying shikimic acid from extracts comprising oil palm phenolics (OPP).

Compositions comprising shikimic acid obtained from oil palm based materials and method of producing thereof

The invention provides new uses and products for treatment of sexual dysfunction and male infertility. The products include bioactive components of extracts from roots of the plantmixed in preparations for topical application and administation.

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A method has been developed for control of molecular weight and molecular weight dispersity during production of polyhydroxyalkanoates in genetically engineered organism by control of the level and time of expression of one or more PHA synthases in the organisms. The method was demonstrated by constructing a synthetic operon for PHA production in E. coli in which the level of PHA synthase activity could be tightly controlled by placement of the synthase behind an inducible promoter. Modulation of the total level of PHA synthase activity in the host cell by varying the concentration of the inducer, isopropyl .beta.-D-thiogalactoside (IPTG), was found to effect the molecular weight of the polymer produced in the cell. Specifically, high concentrations of synthase activity were found to yield polymers of low molecular weight while low concentrations of synthase activity yielded polymers of higher molecular weight. Polymer molecular weight dispersity is also proportional to the amount of synthase activity, with less dispersity in polyhydroxyalkanoate compositions produced in expression systems with an initial burst of synthase activity, and higher levels of molecular weight dispersity in polyhydroxyalkanoate compositions produced in expression systems with the levels of synthase activity varied during synthesis of the polyhydroxyalkanoate.

Method for controlling molecular weight of polyhydroxyalkanoates

A degradation product of a polysaccharide derivative comprising a mixture of oligomers of the polysaccharide derivative, the majority of said oligomers having a molecular weight such that the oligomer conforms to a rod-like configuration.

Degraded polysaccharide derivatives

An insoluble polymeric capsule comprising at least two polymeric components, wherein one of said components is a hydrophilic colloid, and another of said components comprises a degradation product of a cellulose derivative, the degradation product comprising a mixture of oligomers, a majority of said oligomers having a degree of polymerization such that the oligomers conform to a rod-like configuration.

Polymeric capsules, method of making the same, and foodstuffs containing

Degraded polysaccharide derivatives and foodstuffs containing same

Three dimensional glucan matrix compositions are prepared by separating growing yeast from its growth medium, subjecting the yeast with cell walls intact to an alkali material, thereby extracting whole glucan particles having an intact cell wall structure. The whole glucans can then, optionally, be treated with acetic acid to alter the .beta.(1-6) linkages, or with glucanase to alter the .beta.(1-3) linkages. The glucans have viscosity characteristics dependent upon the strain of yeast utilized and are useful as stabilizers or thickeners.

Process for preparing glucanase resistant yeast mutants

Foodstuffs containing novel degraded cellulose derivatives

A paper product treated with a degradation product of a polysaccharide derivative comprising a mixture of oligomers of the polysaccharide derivative, a majority of said oligomers having a degree of polymerization such that the oligomer conforms to a rod-like configuration.

Paper composition and methods therefor

Glucan compositions and process for preparation thereof

The extraction or purification of biomaterials and other products by liquid-liquid extraction in an aqueous system is enhanced by introducing a particulate polymeric adsorbent into the extraction system and agitating the system, whereupon the adsorbent reversibly binds the product or material to be separated from the product, to form a complex, and the complex preferentially partitions into one of the liquid phases. The complex is then separated, and the product recovered from the complex or the remaining liquid. Ion exchange resins comprising beads or ground particles, of 0.01-10 micrometer average diameter, are representative adsorbents.

Liquid-liquid extraction with particulate polymeric adsorbent

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Boston, MA, United States of America

ChoKyun Rha