The General Hospital Corporation

Choi Sungwoon

David R Elmaleh

Alan J Fischman

Described herein are piperidine and piperazine compounds useful for treating neurodegenerated diseases characterized by a lack of dopamine neuron activity. The compounds are also useful for imaging dopamine neurons.

Diagnostic and therapeutic alkyl piperidine/piperazine compounds and process

Piperidine or piperazine compounds useful for treating neurodegenerated diseases characterized by the lack of dopamine neurons activity or for imaging the dopamine neurons are provided. The compounds are characterized by the formulae: wherein:n is an integer of 1 to 6; X, Y, Zand Zcan be the same or different and are hydrogen, halo, haloalkyl, alkyl, aryl, (C-C) alkoxy, N-alkyl, (C-C) acyloxy, N-alkylene, &#x2014;SH, &#x2014;SR, wherein R is from the same group as Rand Rand can be the same or different than Rand R, amino, nitro, cyano, hydroxy, C(&#x2550;O)OR, &#x2014;C(&#x2550;O)NRR, NRR, or S(&#x2550;O)Rwhereinis 1 or 2, and Rto Rare independently hydrogen or (C-C) alkyl;

Growing community of inventors

Sharon, MA, United States of America

Choi Sungwoon