Fujisawa Pharmaceutical Company, Ltd.

Chiyoshi Kasahara

Teruo Kyoto Oku

Masashi Hashimoto

Hiroshi Kayakiri

Katsuya Nakamura

Eishiro Todo

Masayoshi Murata

Masakuni Okuhara

Kozo Sawada

Yasuhisa Tsurumi

Takehiko Ohkawa

Nobuharu Shigematsu

Takayuki Namiki

Motohiro Hino

Yukihisa Baba

Akihiko Fujie

Kumiko Nitta

Toshiro Iwamoto

Yoshikuni Ito

Kazuo Sakane

Keiji Hemmi

Kohji Kawabata

Hideo Tsutsumi

Hidenori Ohki

Masahiro Neya

Kazuhiko Take

Shinji Shigenaga

Hitoshi Sawada

Hidenori Azami

Yoshiteru Eikyu

Masataka Morita

Tatsuya Zenkoh

Kazuo Nakai

Yoshihiro Murakami

A compound of the formula (I): in which Z, R , R , R , R , R , R , R and R are each as defined in the description, or a salt thereof. The object compound of the present invention has pharmacological activities such as Tachykinin antagonism, and is useful for manufacture of a medicament for treating or preventing Tachykinin-mediated diseases.

Benzhydryl derivatives

Endothelin antagonists

An oxaspiro �2,5!octane derivative of the formula: ##STR1## useful in inhibiting angiogenesis in solid tumors.

Oxaspiro(2,5)octane derivative

Oxaspiro�2,5! octanes of the formula ##STR1## inhibit angiogenesis and are particularly suitable for the treatment of solid tumors. In preferred embodiments, R.sup.1 is a carbamoyl derivative, R.sup.2 is an alkoxy substituent and R.sup.3 is ##STR2## Pharmaceutical salts of these compounds, such as methyl, amonium and organic amine salts also exhibit desirable properties.

Oxaspiro�2,5! octane derivative

A compound having antimicrobial activity of the following general formula: ##STR1## wherein R.sup.1 is hydrogen or hydroxy, R.sup.2 is hydrogen or hydroxy, R.sup.3 is hydroxy or hydroxysulfonyloxy, with proviso that when R.sup.1 is hydrogen, R.sup.2 is hydrogen, or a phamaceutically acceptable salt thereof. The compound can be used in a method for treating infectious diseases caused by pathogenic microorganism.

Antimicrobial polypeptide compound a pharmaceutical composition

A polypeptide compound having antimicrobial activity of the following general formula: ##STR1## wherein R.sup.1 is hydrogen or acyl group, R.sup.2 is hydroxy or acyloxy,

Polypeptide compound and a process for preparation thereof

The invention relates to carbapenem derivatives useful as antimicrobial agents, more particularly to intermediate compounds for the preparations thereof of the formula ##STR1##

Processes for preparing carbapenem derivatives

A compound of the formula: ##STR1## wherein R.sup.1 -A- is a group of the formula: ##STR2## in which R.sup.1 is aryl or a heterocyclic group, each of which may be substituted with substituent(s) selected from the group consisting of lower alkyl, lower alkoxy, lower alkylthio, halo(lower)alkyl, acyl, acylamino and halogen, or lower alkyl which may be substituted with a heterocyclic group optionally substituted with acyl, and

Diphosphonic acid compounds, and pharmaceutical composition comprising

A compound of the formula: ##STR1## wherein R' is phenyl, phenyl which is substituted with halogen, lower alkyl, lower alkoxy, halo lower alkyl, lower alkylamino, lower alkylthio, phenoxy, carboxy, lower alkoxycarbonyl, carboxy lower alkyl, lower alkoxycarbonyl, lower alkyl, cyclo lower alkyl; lower alkyl which is substituted with carboxy or lower alkoxyoxycarbonyl; or pyrimidinyl, pyridyl or pyridyl which is substituted with lower alkyl;

Benzothiadiazine compounds, and pharmaceutical composition comprising

The invention relates to compounds having aldose reductase-inhibitory activity of the formula: ##STR1## in which R.sup.1 and R.sup.2 are each hydrogen, halogen, lower alkoxy or halo(lower)alkyl,

Quinazoline derivatives and process for their production

A compound of the formula: ##STR1## wherein R.sup.1 --A-- is a group of the formula: ##STR2## in which R.sup.1 is aryl or a heterocyclic group, each of which may be substituted with substituent(s) selected from the group consisting of lower alkyl, lower alkoxy, lower alkylthio, halo(lower)alkyl, acyl, acylamino and halogen, or lower alkyl which may be substituted with a heterocyclic group optionally substituted with acyl, and

Diphosphonic acid compounds, processes for the preparation thereof and

The invention relates to compounds of the formula: ##STR1## in which R.sup.1 and R.sup.2 are each hydrogen, halogen, lower alkoxy or halo(lower)alkyl,

Quinazoline derivatives, compositions thereof and their use in treating

Growing community of inventors

Ikeda, Japan

Chiyoshi Kasahara