Daicel Chemical Industries, Ltd.

Nagoya University

Daicel Corporation

Nagoya Industrial Science Research Institute

Chiyo Yamamoto

Yoshio Okamoto

Masami Kamigaito

Tomoyuki Ikai

Takateru Kubota

Shunsuke Kondo

Provided is a complex obtained by reacting a polymer compound derivative obtained by modifying part of the hydroxy groups or amino groups of a polymer compound having the hydroxy groups or amino groups with a compound represented by the following general formula (I) with one or more kinds of compounds represented by the following general formulae (II) to (V): (I) A-X&#x2014;Si(Y)R; (II) M(OR)R; (III) Al(OR)R; (IV) Mg(OR)R; and (V) [Si(OR)R]&#x2014;(X)&#x2014;[Si(OR)R].

Separating agent for optical isomer

The present invention provides: a polysaccharide derivative containing a structure wherein hydrogen atoms in a hydroxyl group at the 2-position and the 3-position of a structure unit of polysaccharide are substituted with different substituents respectively represented by a specific general formula and a separating agent for optical isomers which contains such a polysaccharide derivative. The present invention can provide a novel polysaccharide derivative which has excellent optical isomer separating ability, making it suitable as a separating agent for optical isomers, and can provide a separating agent for optical isomers which contains the polysaccharide derivative.

Polysaccharide derivative and separating agent for optical isomer containing the same

A filler for optical isomer separation which: allows a polymer compound derivative to be immobilized on the surface of a carrier at a high ratio and is excellent in optical separation ability. The filler is characterized in that the filler is obtained by modifying part of the hydroxy or amino groups of a polymer compound having the hydroxy or amino groups with molecules of a compound represented by the following general formula (I): A-X&#x2014;Si(Y)R, and is carried by a carrier through chemical bonding.

Filler for optical isomer separation

A polymer compound derivative, obtained by modifying part of the hydroxy or amino groups of a polymer compound having the hydroxy or amino groups with molecules of a compound represented by the following general formula (I): A-X&#x2014;Si(Y)R(I), where A represents a reactive group which reacts with a hydroxy or amino group, X represents an alkylene group which has 1 to 18 carbon atoms and which may have a branch, or an arylene group which may have a substituent, Y represents a reactive group which reacts with a silanol group to form a siloxane bond, R represents an alkyl group which has 1 to 18 carbon atoms and which may have a branch, or an aryl group which may have a substituent, and n represents an integer of 1 to 3.

A separating agent which combines a high optical resolving power inherent in polysaccharide derivatives with sufficient solvent resistance and a method with which the separating agent can be produced efficiently in short steps. The separating agent for enantiomeric isomers is characterized in that a polymerizable polysaccharide derivative of a polysaccharide derivative having polymerizable functional groups and a polymerizable monomer having polymerizable unsaturated groups are copolymerized with a carrier having polymerizable functional groups to be chemically bound mutually. The separating agent is preferably used for high performance liquid chromatography (HPLC) and has an excellent solvent resistance.

Separating agent for enantiomeric isomers and method of producing the same

Provided is a chitosan derivative having a high optical resolving power. Specifically provided is a chitosan derivative represented by the following Formula (I). wherein Rrepresents an aliphatic group or an aromatic group having a carbon number of 1 to 30 which may have a substituent; Rrepresents a substituent originating from an isocyanic acid derivative, carboxylic acid, ester, acid halide, acid amide compound, halide compound, aldehyde, or alcohol; and n is an integer of 5 or more.

Chitosan derivative and method of producing same

The present invention provides a separating agent for enantiomeric isomers which exhibits high optical resolving power together with solvent resistance. That is, the present invention provides a separating agent for enantiomeric isomers including a polysaccharide derivative such as a carbamate derivative or ester derivative of cellulose or amylose carried on a porous carrier such as silica gel, in which the porous carrier having an epoxy group and part of the hydroxyl groups of the polysaccharide derivative are chemically bonded.

Separating agent for enantiomeric isomers

There is provided a process for producing beads for enantiomeric isomer resolution with a satisfactory separation efficiency. The beads for enantiomeric isomer resolution include a polysaccharide derivative, in which the polysaccharide derivative has a structure crosslinked at the 6-position hydroxy group of constituent units of the polysaccharide with a crosslinking agent. The process for producing the beads for enantiomeric isomer resolution includes: the step of adding dropwise an organic solvent solution of the polysaccharide derivative to a coagulation bath being stirred to thereby produce beads; the step of taking out the beads and then optionally drying the same after washing; and the step of reacting the beads with a crosslinking agent in an organic solvent to react at least part of the 6-position hydroxy groups in the constituent units of the polysaccharide with the crosslinking agent, thereby obtaining a reaction mixture containing beads having a crosslinked structure.

Bead for enantiomeric isomer resolution and process for producing the same

The present invention provides a separating agent for enantiomeric isomers, which has an excellent ability to identify asymmetry. That is, the present invention relates to a separating agent for enantiomeric isomers which includes as an effective component a polysaccharide derivative having a bicyclic or more structure having an aromatic, alicyclic, or heterocyclic ring.

Separating agent including polysaccharide derivative having a polycyclic structure

The present invention provides a separating agent for enantiomeric isomers exhibiting high separation power. That is, the present invention provides a separating agent for enantiomeric isomers including, as an active ingredient, a polysaccharide derivative having at least part of hydrogen atoms of hydroxyl groups of a polysaccharide such as cellulose or amylose substituted by at least one of atomic groups represented by the following general formulae (I) and (II): (in the formulae, R represents a substituted or unsubstituted aromatic group, or a linear, branched, or cyclic aliphatic group).

Separating agent for optical isomer and method for preparation thereof

The present invention provides a separating agent for enantiomeric isomers having no large UV absorption, as represented by an aromatic group, and having high asymmetric recognizability, particularly, high asymmetric recognizability in an aqueous mobile phase, or a separating agent for enantiomeric isomers containing a polysaccharide alicyclic ester derivative free from an aromatic group as an effective component.

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Aichi, Japan

Chiyo Yamamoto