Taiwanj Pharmaceuticals Co., Ltd.

Chiung Wen Wang

Yan-Feng Jiang

Syaulan S Yang

Chia-Hao Chang

Kuang Yuan Lee

Mei-chi Hsu

Ting-ni Huang

Meng Hsien Liu

Yu-Shiou Fan

Sheng Hung Liu

Hao Shiuan Liu

Meng-hsien Liu

Ying-chu Shih

Yan-feng Jiang

The compounds represented by Formula (I), which are peripheral alkyl and alkenyl chains extended benzene derivatives, are useful as dual autotaxin (ATX)/histone deacetylase (HD AC) inhibitors. These compounds may be included in a pharmaceutical composition along with a pharmaceutically acceptable carrier, and be used in a therapeutically effective amount for prophylaxis or treatment of various diseases and disorders.

Peripheral alkyl and alkenyl chains extended benzene derivatives and pharmaceutical composition including the same

The present disclosure relates to a compound of Formula I, or a geometric isomer, enantiomer, diastereomer, racemate, atropisomer, pharmaceutically acceptable salt, prodrug or solvate thereof. The present disclosure further relates to a composition comprising the compound of Formula (I). The compound and the composition described herein can be used to inhibit NADPH oxidase activity. 

NADPH oxidase inhibitors, pharmaceutical composition comprising the same, and application thereof

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Zhubei, Taiwan

Chiung Wen Wang