Biocon Limited

Chittnalli Ramegowda Naveen Kumar

Sanjay Tiwari

Harish Iyer

Anuj Goel

Mukesh Babuappa Patale

Mayank Kumar Garg

Saurabh Garg

Sulekha Joshi

Bimal Kumar

Deepthy Sathyanathan

The present invention demonstrates the utility of carbonic acid amides such as urea or its derivatives, carbamates, carbodiimides & thiocarbamides as nitrogenous supplements in fermentation media for production of recombinant proteins to achieve enhanced bioconversion rates and peptides like insulin and insulin analogs, exendin and enzymes such as lipase using methanol inducible fungal expression systems such as

Fermentation medias and processes thereof

The present invention demonstrates the utility of carbonic acid amides such as urea or its derivatives, carbamates, carbodiimides & thiocarbamides as nitrogenous supplements in fermentation media for production of recombinant proteins to achieve enhanced bioconversion rates and peptides like insulin and insulin analogues, exendin and enzymes such as lipase using methanol inducible fungal expression systems such as

The invention provides a process for the production of lipase inhibitors via an improvised fermentation process characterized in that a combinatorial feeding of linoleic acid or its esters or salts thereof and an omega-9 fatty acid, preferably oleic acid and/or its derivatives is employed during said process resulting in an improved yield co-efficient, productivity further providing ease of operation.

Fermentation process for higher yield coefficient of lipase-inhibitor with respect to consumed fatty acid

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Bengaluru, India

Chittnalli Ramegowda Naveen Kumar