Council of Scientific and Industrial Research

Chitra Mandal

Bikas Chandra Pal

Kaushik Bhattacharya

Diviya Sinha

Ranjita Das

Dilip Kumar Bhattacharya

Sayantani Sarkar

Mitali Chatterjee

Suman Kumar Samanta

Vineeta Sharma

The present invention relates to two main components, mahanine and mahanimbine (dehydroxy-mahanine) fromfor the treatment of glioblastoma and cervical carcinoma. Mahanimbine exhibited anti-cancer activity against lymphoid leukemia, myeloid leukemia, glioma, cervical carcinoma, pancreatic, colon and lung cancers in nineteen cells of different genetic status. C-3 hydroxy and NH groups are responsible contributing groups for their cytotoxicity. Mahanine reduced the doses of cisplatin and paclitaxel in cervical cancer showing better efficacy and useful as an adjunct chemotherapeutic agent to reduce toxicity these two drugs. A new cheap process for this preparation was established. EtOAc extract containing alkaloids enriched with mahanimbine and mahanine, is active against glioma and cervical cancers. Mahanine is targeting the chaperone Hsp90 which led to the proteasome-dependent degradation of several Hsp90-client proteins in diverse carcinoma types, glioblastoma, cervical carcinoma and pancreatic adenocarcinoma irrespective of their tissue origins thereby killing the cancer cells.

Process for the isolation of organic compounds useful for the treatment of cancer

This invention relates to identification of a new key marker, namely, 9-O-Acetylated Sialoglycoconjugate with the help of a known 9-O-Acetylsialic acid binding lectin, AchatininH useful for the detection of minimal residual disease (MRD) and prediction of relapse by a lymphoproliferation assay in acute lymphoblastic leukaemia (ALL).

Simple method for the detection of minimal residual disease to predict

This invention relates to identification of a new key marker namely 9-O-Acetylated sialoglycoconjugate with the help of a known 9-O acetylsialic acid binding lectin, Achatinin-H useful for the diagnosis of visceral leishmaniasis, by a rapid, accurate haemagglutination assay.

Method for diagnosing visceral leishmaniasis in a patient by

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Chitra Mandal