Nippon Steel Sumitomo Metal Corporation

Nippon Steel Corporation

Chugai Seiyaku Kabushiki Kaisha

National Center of Neurology and Psychiatry

Chisato Wakabayashi

Nobuhiro Fujita

Hiroyuki Kawata

Masafumi Azuma

Manabu Takahashi

Kohichi Sano

Takayuki Nozaki

Riki Okamoto

Naoki Maruyama

Naoki Yoshinaga

Akinobu Murasato

Noriyuki Suzuki

Kaoru Kawasaki

Natsuko Sugiura

Yasunobu Miyazaki

Fuminori Watanabe

Seiji Furusako

Hiroshi Yoshida

Koichi Sato

Takeshi Yamamoto

Kunio Hayashi

Shinichiro Watanabe

Tohru Okada

Hideki Hamatani

Masaharu Oka

Akinobu Minami

Yasuharu Sakuma

Hajime Hasegawa

Sho Matsui

Hiroshi Kunugi

Tsuyoshi Oki

The present invention provides a novel therapeutic agent for mental illness. The therapeutic agent for mental illness comprises an IL-6 inhibitor as an active ingredient.

Therapeutic agent for mental illness comprising IL-6 inhibitor as active ingredient

By obtaining a spot-welded joint being a spot-welded joint formed by overlapping a plurality of pieces of steel plates (A,B) and performing spot welding on the steel plates, including a high-strength steel plate whose tensile strength is 750 (MPa) to 2500 (MPa), being at least one piece of steel plate out of the plurality of pieces of steel plates, in which a carbon equivalent Ceq of the high-strength steel plate is 0.20 mass % to 0.55 mass %, and ten or more of iron-based carbides in each of which a length of a longest portion is 0.1 (&#x3bc;m) or more exist in a square regionwithin a heat-affected zoneof a cross section that passes through a center of a welding mark, and is cut along a plate thickness direction of the steel plates (A,B), a cross tensile strength of the spot-welded joint to be formed is improved.

Spot-welded joint and spot welding method

A high-strength cold-rolled steel sheet includes, as a component composition, by mass %: C: 0.075% to 0.300%; Si: 0.30% to 2.50%; Mn: 1.30% to 3.50%; P: 0.001% to 0.050%; S: 0.0001% to 0.0100%; Al: 0.001% to 1.500%; and N: 0.0001% to 0.0100%, in which a surface microstructure contains residual austenite of 3% to 10% and ferrite of 90% or less by volume fraction, an inner microstructure at a depth of t/4 from the surface assuming that a sheet thickness is t contains residual austenite of 3% to 20% by volume fraction, a ratio Hvs/Hvb between a surface hardness Hvs of the steel sheet surface and a hardness Hvb at a depth of &#xbc; of the thickness is more than 0.75 to 0.90, and a maximum tensile strength is 700 MPa or more.

High-strength cold-rolled steel sheet and method for producing the same

Provided is a high-strength hot-dip galvanized steel sheet having excellent plating adhesion, formability, and hole expandability with an ultimate tensile strength of 980 MPa or more, the hot-dip galvanized steel sheet comprising a hot-dip galvanized layer formed on a surface of a base steel sheet. The base steel sheet contains, by mass %, C: 0.05% to 0.4%; Si: 0.01% to 3.0%; Mn: 0.1% to 3.0%; Al: 0.01 to 2.0%; in which Si+Al&#x3e;0.5%, P: limited to 0.04% or less; S: limited to 0.05% or less; N: limited to 0.01% or less; and a balance including Fe and inevitable impurities, a microstructure of the base steel sheet contains 40% or more by total volume fraction of martensite and bainite, 8% or more by volume fraction of residual austenite, and a balance of the microstructure being ferrite or ferrite and 10% or less by volume fraction of pearlite. The martensite contains 10% or more by total volume fraction of two or more kinds of three kinds of martensites (1), (2), and (3), and the hot-dip galvanized layer contains less than 7 mass % of Fe.

High-strength hot-dip galvanized steel sheet and high-strength alloyed hot-dip galvanized steel sheet having excellent plating adhesion, formability, and hole expandability with tensile strength of 980 MPa or more and manufacturing method therefor

A hot-dip galvanized steel sheet includes: a steel sheet; and a plated layer on a surface of the steel sheet, a microstructure contains, by volume fraction, equal to or more than 20% and equal to or less than 99% in total of one or two of martensite and bainite, a residual structure contains one or two of ferrite, residual austenite of less than 8% by volume fraction, and pearlite of equal to or less than 10% by volume fraction, tensile strength is equal to or greater than 980 MPa, the plated layer is a hot-dip galvanized layer which contains oxides including one or two or more of Si, Mn, and Al, contains equal to or less than 15 mass % of Fe, and a remainder including Zn, Al, and unavoidable impurities, and when a cross section including the steel sheet and the hot-dip galvanized layer is seen in a sheet thickness direction, a projected area ratio is equal to or more than 10% and equal to or less than 90%.

Hot-dip galvanized steel sheet and manufacturing method thereof

The present invention provides a high-strength steel sheet excellent in impact resistance. The high-strength steel sheet contains predetermined contents of C, Si, Mn, P, S, Al, Ti, N, and O, with the balance being iron and inevitable impurities, and has a steel sheet structure in which, in a &#x215b; thickness to &#x215c; thickness region across &#xbc; of a sheet thickness, 1 to 8% retained austenite is contained in volume fraction, an average aspect ratio of the retained austenite is 2.0 or less, an amount of solid-solution Mn in the retained austenite is 1.1 times an average amount of Mn or more, and TiN grains having a 0.5 &#x3bc;m average grain diameter or less are contained, and a density of AlN grains with a 1 &#x3bc;m grain diameter or more is 1.0 pieces/mmor less, wherein a maximum tensile strength is 900 MPa or more.

High-strength steel sheet excellent in impact resistance and manufacturing method thereof, and high-strength galvanized steel sheet and manufacturing method thereof

A spot welding method able to simply prevent liquid metal embrittlement cracks in spot welding of plated steel sheets, comprising, before spot welding, removing the plating at least in a zone including the inside of a circle centered at a scheduled location where the center of the nugget is formed and having an outer circumference of the inside of the outer edge of a weld affected zone or a zone at the mated surfaces of the steel sheets to be welded at the inside of a circle sharing a center of a scheduled location becoming the center of the nugget formed at the mated surfaces of the steel sheets and having an outer circumference of the inside of the outer edge of a weld affected zone.

Method of spot welding

A steel sheet including, by mass %, C: more than 0.100% and 0.500% or less, Si: 0.0001% or more and less than 0.20%, Mn: more than 0.20% and 0.50% or less, Al: 3.0% or more and 10.0% or less, N: 0.0030% or more and 0.0100% or less, Ti: more than 0.100% and 1.000% or less, P: 0.00001% or more and 0.0200% or less, S: 0.00001% or more and 0.0100% or less, and a remainder including Fe and impurities, in which a sum of a C content and a Ti content satisfies 0.200&#x3c;C+Ti&#x2264;1.500 by mass %, a product of an Al content and an Si content satisfies Al&#xd7;Si&#x2264;0.8 by mass %, and a specific gravity is 5.5 to less than 7.5.

High-strength low-specific-gravity steel sheet having superior spot weldability

High strength steel plate with an ultimate tensile strength of 900 MPa or more which is excellent in hydrogen embrittlement resistance characterized in that, in the structure of the steel plate, (a) by volume fraction, ferrite is present in 10 to 50%, bainitic ferrite and/or bainite in 10 to 60%, and tempered martensite in 10 to 50%, and (b) iron-based carbides which contain Si or Si and Al in 0.1% or more are present in 4&#xd7;10(particles/mm) or more.

High strength steel plate with ultimate tensile strength of 900 MPa or more excellent in hydrogen embrittlement resistance and method of production of same

A galvanized steel sheet includes a steel sheet and a plating layer on the surface of the steel sheet, in which the steel sheet includes, as a steel chemical composition, by mass %, C: 0.05 to 0.40%, Si: 0.5 to 3.0% and Mn: 1.5 to 3.0%, a microstructure of the steel sheet includes ferrite, bainite, by volume fraction, 30% or more of a tempered martensite, and 8% or more of an austenite, and tensile strength of the steel sheet is 980 MPa or more, and the plating layer includes an oxide including at least one chemical element selected from Si, Mn and Al, and when seen at a cross section including the steel sheet and the plating layer in a plate thickness direction, a projection area fraction of the oxide is 10% or more.

Galvanized steel sheet and method of manufacturing the same

Provided is a high-strength hot-dip galvanized steel sheet having excellent plating adhesion, formability, and hole expandability with an ultimate tensile strength of 980 MPa or more, the hot-dip galvanized steel sheet comprising a hot-dip galvanized layer formed on a surface of a base steel sheet. The base steel sheet contains, by mass %, C: 0.05% to 0.4 %; Si: 0.01% to 3.0%; Mn: 0.1% to 3.0%; Al: 0.01 to 2.0%; in which Si+Al &#x3e;0.5%, P: limited to 0.04% or less; S: limited to 0.05% or less; N: limited to 0.01% or less; and a balance including Fe and inevitable impurities, a microstructure of the base steel sheet contains 40% or more by total volume fraction of martensite and bainite, 8% or more by volume fraction of residual austenite, and a balance of the microstructure being ferrite or ferrite and 10% or less by volume fraction of pearlite. The martensite contains 10% or more by total volume fraction of two or more kinds of three kinds of martensites (1), (2), and (3), and the hot-dip galvanized layer contains less than 7 mass % of Fe.

Disclosed is a hot-rolled steel sheet including, by mass %, C:0.02% to 0.5% of C, and the sum of the content of Si and the content of Al is 1.0% to 4.0%. An average pole density of an orientation group from {100}&#x3c;011&#x3e; to {223}&#x3c;110&#x3e; is 1.0 to 6.5, and a pole density of a crystal orientation {332}&#x3c;113&#x3e; is 1.0 to 5.0. A microstructure includes, by of an area ratio, 2% to 30% of retained austenite, 20% to 50% of ferrite, and 10% to 60% of bainite. rC that is a Lankford value in a direction orthogonal to a rolling direction is 0.70 to 1.10, and r30 that is a Lankford value in a direction forming an angle of 30&#xb0; with the rolling direction is 0.70 to 1.10.

Hot-rolled steel sheet and production method thereof

Disclosed is a high-strength hot-dip galvanized steel sheet having small material anisotropy and excellent formability with an ultimate tensile strength of 980 MPa or more. The hot-dip galvanized steel sheet includes a hot-dip galvanized layer formed on a surface of a base steel plate. The base steel plate contains C, Si, Mn, O, P, S, Al and N within predetermined ranges and a balance including Fe and inevitable impurities. The hot-dip galvanized layer contains Fe at less than 7 mass % or 7 to 15 mass % and a balance including Zn, Al, and inevitable impurities.

High-strength hot-dip galvanized steel sheet and high-strength alloyed hot-dip galvanized steel sheet having excellent formability and small material anisotropy with ultimate tensile strength of 980 MPa or more

A steel sheet, including: as chemical components, by mass %, 0.05% to 0.35% of C; 0.05% to 2.0% of Si; 0.8% to 3.0% of Mn; 0.01% to 2.0% of Al; equal to or less than 0.1% of P; equal to or less than 0.05% of S; equal to or less than 0.01% of N; and the balance including iron and inevitable impurities, wherein the steel sheet comprises 50% or more of a ferrite phase, a bainite phase, and a tempered martensite phase, 3% or more of a retained austenite phase, and 50% or more of the crystal grains of the retained austenite phase satisfy Expression 1, wherein a carbon concentration at a position of center of gravity is Cgc and a carbon concentration at a grain boundary is Cgb.

Steel sheet and method of manufacturing steel sheet

This high-strength steel sheet includes by mass percentage: 0.05 to 0.4% of C; 0.1 to 2.5% of Si; 1.0 to 3.5% of Mn; 0.001 to 0.03% of P; 0.0001 to 0.01% of S; 0.001 to 2.5% of Al; 0.0001 to 0.01% of N; 0.0001 to 0.008% of O; and a remainder composed of iron and inevitable impurities, wherein a steel sheet structure contains by volume fraction 10 to 50% of a ferrite phase, 10 to 50% of a tempered martensite phase, and a remaining hard phase, wherein a 98% hardness is 1.5 or more times as high as a 2% hardness in a range from &#x215b; to &#x215c; of a thickness of the steel sheet, wherein a kurtosis K* of the hardness distribution between the 2% hardness and the 98% hardness is &#x2212;1.2 to &#x2212;0.4, and wherein an average crystal grain size in the steel sheet structure is 10 &#x3bc;m or less.

High-strength steel sheet and high-strength zinc-coated steel sheet which have excellent ductility and stretch-flangeability and manufacturing method thereof

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Tokyo, Japan

Chisato Wakabayashi