Nippon Kayaku Kabushiki Kaisha

Chisato Tomiyama

Akira Masuda

Keiichirou Yamamoto

Keiko Sekine

Takeshi Onda

Ken Yamakawa

Yasushi Yoneta

Setsuko Niitsuma

Yuichi Akatsu

Ayaka Mochizuki

A physiologically active substance-conjugated block copolymer having enhanced efficacy and/or safety is provided by enhancing the property of penetrating into a target diseased tissue and/or enhancing excretability, compared to known physiologically active substance-conjugated block copolymer, and suppressing sensitization of the physiologically active substance to normal tissues other than a target diseased tissue. Disclosed is a block copolymer including a polyethylene glycol segment connected with a polyamino acid derivative segment conjugated with a physiologically active substance, in which the molecular weight of the block copolymer is from 2 kilodaltons to 15 kilodaltons, and the light scattering intensity of a 1 mg/mL aqueous solution of the physiologically active substance-conjugated block copolymer as measured with a laser light scattering photometer is at least twice or more the light scattering intensity of toluene.

Block copolymer conjugate of physiologically active substance

Growing community of inventors

Tokyo, Japan

Chisato Tomiyama