Medtronic Ave, Inc.

Smith + Nephew

C. R. Bard, Inc.

Tyco Healthcare Group LP

Other

Medtronic Vascular, Inc.

Covidien LP

Chirag B Shah

Eugene Tedeschi

David Rork Swisher

Richard M Braga

Mark A Vess

Richard A Gambale

Stephen J Forcucci

Laurel L Wolfgang

John A Hudson

Michael F Weiser

Harish A Patel

Sean Forde

Ronald F Vitaris

David G Heagle

E David Fink

Sharon A Mulligan

Alain Tranchemontagne

Brian Dowd

Hansen P Swaniker

Kate Ward

Scott Orr

John R Fagan

Mike Weiser

Hansen Swaniker

David Heagle

A system for subatmospheric pressure therapy in connection with healing a wound is provided. The system includes a wound dressing cover dimensioned for positioning relative to a wound bed of a subject to establish a reservoir over the wound bed in which subatmospheric pressure may be maintained, a subatmospheric pressure mechanism including, a housing, a vacuum source disposed in the housing, and a collection canister in fluid communication with the vacuum source. The system further includes an exudate conduit in fluid communication with the wound dressing and the collection canister for collecting exudate removed from the reservoir and deposited in the collection canister under influence of the vacuum source and a vent conduit in fluid communication with the collection canister and the wound dressing for introducing air into the reservoir to facilitate flow of exudate through the exudate conduit.

System for providing continual drainage in negative pressure wound therapy

A wound dressing includes one or more layers containing a first anti-microbial agent and/or at least one zinc-containing agent.

Wound dressings with anti-microbial and zinc-containing agents

A wound dressing includes one or more layers containing a first anti-microbial agent and at least one of: a chelating agent, and a second anti-microbial agent.

Wound dressings with anti-microbial and chelating agents

The present invention provides a system for delivering a therapeutic agent into tissue in combination with an implant device (). Preferably the therapeutic substance is contained within a pellet form () that is deliverable into the interior of the device () after it has been implanted. In a preferred embodiment the implant device () comprises a flexible coiled spring body, the coils () of which have the proper diameter and spacing to contain the pellet () within the interior of the device () to contact the therapeutic agent. In treatment of ischemic tissue such as that of the myocardium of the heart, the mechanical irritation of the tissue caused by the implanted device () can help to provide an angiogenic effect. Additionally, the cavity () provided by the interior of the device () permits blood to pool around the pellet () and mix with the therapeutic agent. Several delivery systems have provided for delivering the implant and pellet () sequentially or simultaneously.

Agent delivery systems

Coatings are provided in which biopolymers may be covalently linked to a substrate. Such biopolymers include those that impart thromboresistance and/or biocompatibility to the substrate, which may be a medical device. Coatings disclosed herein include those that permit coating of a medical device in a single layer, including coatings that permit applying the single layer without a primer. Suitable biopolymers include heparin complexes, and linkage may be provided by a silane having isocyanate functionality.

Thromboresistant coated medical device

Thromboresistant coating composition

The invention includes systems and methods for stimulating intramuscular angiogenesis by placing a biocompatible device within the tissue of a muscle. The biocompatible device is dimensionally adapted for placement within the tissue of a muscle. Placement of the biocompatible device within the muscle can take place according to the method of the invention by using techniques familiar to those of ordinary skill in the art. Illustrative techniques for placement of the device within the myocardium comprise one practice of the method of the invention.

Systems and methods for imbedded intramuscular implants

Methods are provided for delivering nitric oxide to the vascular tissue of a patient to inhibit or prevent restenosis or improve vascular function following various surgical procedures or associated with various NO-related conditions. The disclosed methods comprise contacting the vascular tissue of a patient with a medical device coated with a coating comprising nitric oxide associated with and releaseable from a polyurea network formed from the reaction on said medical device of a polyisocyanate; an amine donor and/or hydroxyl donor; an isocyanatosilane adduct having terminal isocyanate groups and at least one hydrolyzable alkoxy group bonded to silicon; and optionally a polymer selected from the group consisting of polyethylene oxide, polyvinyl pyrrolidone, polyvinyl alcohol, polyethylene glycol, and polyacrylic acid.

Uses for medical devices having a lubricious, nitric oxide-releasing coating

The present invention provides a catheter positioning system which serves to control and stabilize a distal end of a catheter at a treatment site within a patient so that a medical procedure can be performed with accuracy. Generally, the positioning system operates by providing a deformable mechanical members at the distal end of the catheter which can be operated from the proximal end of the catheter to extend radially outward to engage surrounding tissue adjacent to treatment site. In one embodiment of the invention a flexible superstructure comprising the plurality of flexible veins extending longitudinally along the distal end of the catheter can be deformed to bow radially outward to engage surrounding tissue. The distal tip of the catheter joined to one of the veins was correspondingly displaced or rotated angularly as the veins bow outward. In another embodiment radially projecting fingers are joined to the distal end of the catheter, which remain retracted during navigation of the catheter to the treatment site then are extended outward to penetrate the tissue and secure the catheter at the treatment site upon being actuated from the proximal end of the catheter by a physician. Methods of positioning a catheter are also disclosed. The inventive device and method are particularly useful in catheter based procedures carried out in large body lumens or in cavities of body organs. In particular, the invention may be useful in delivering implants percutaneously through the left ventricle into the myocardium of the heart.

Catheter positioning systems

A coating composition is provided comprising hyaluronic acid or a salt thereof and a blocked polyisocyanate in a solvent comprising water. A method is provided for preparing the coating on a substrate comprising forming a coating mixture of hyaluronic acid or a salt thereof and a blocked polyisocyanate in a solvent comprising water; applying the coating mixture to the substrate; and curing the coating.

Article with biocompatible coating

Method for preparing a biocompatible coating

Growing community of inventors

North Attleboro, MA, United States of America

Chirag B Shah