National Chung Hsing University

Symphogen A/s

Center of Disease Control Department of Health

Chiou-Ying Yang

Finn C Wiberg

Jacqueline Sharon

John S Haurum

Vincent W Coljee

The present invention relates to an isolated polypeptide antigen of, comprising at least an amino acid sequence selected from the group consisting of: (a) SEQ ID NOs: 1-5; (b) an amino acid sequence having at least 80% sequence identity to SEQ ID NOs: 1, 3, 4 or 5; (c) an amino acid sequence having at least 60% sequence identity to SEQ ID NO: 2; and (d) a fragment of the amino acid sequence according to (a) to (c); wherein the polypeptide having the amino acid sequence according to (b) to (d) has immunostimulatory activity. The universal polypeptide antigens ofcan be used in the universal vaccine preparation. The corresponding antibodies can be used in the diagnostic and treatment of

Acinetobacter baumannii antigens and the uses thereof

The invention relates to a method for manufacturing a recombinant polyclonal protein composition, in particular a recombinant polyclonal antibody composition. The method comprises obtaining a collection of cells transfected with a library of variant nucleic acid sequences, wherein each call in the collection is transfected with and capable of expressing one member of the library, which encodes a distinct member of a polyclonal protein that binds a particular antigen and which is located at the same single site in the genome of individual cells in said collection, wherein said nucleic acid sequence is not naturally associated with said cell in the collection. The cells are cultured under suitable conditions for expression of the polyclonal protein, which is obtained from the cells or culture supernatant. The present method is suitable for manufacturing recombinant polyclonal antibodies, thereby making available a superior replacement of plasma-derived therapeutic immunoglobulin products.

Method for manufacturing recombinant polyclonal proteins

Present invention provides a monoclonal antibody binding tobacteria and its target antigen Ag473, which include the sequences of its polynucleotide and its amino acid, wherein thebacteria can beor; and wherein Ag473 can be made into a vaccine or a diagnostic or therapeutic reagent.

Growing community of inventors

Taichung, Taiwan

Chiou-Ying Yang