Amgen Inc.

Other

Imaginab, Inc.

Chio Mui Chan

Elaheh Binabaji

Christopher James Sloey

Sekhar Kanapuram

Huanchun Cui

Jean M Gudas

Tove Olafsen

Daulet Kadyl Satpayev

Junfen Ma

Daniel Shir

Michael Yuri Torgov

Hadley Krizner

Diana Woehle

Provided herein are formulations of PCSK9-binding polypeptides, such as those comprising evolocumab, that comprise N-acetyl arginine and have reduced viscosities when compared to formulations lacking N-acetyl arginine. Provided herein are also methods of formulating such compositions that are advantageous in that they conserve certain components. Such formulations comprising PCSK9-binding polypeptides can be administered to patients to treat and/or prevent PCSK9-related diseases, conditions, and disorders.

Low-viscosity, high concentration evolocumab formulations and methods of making the same

The present disclosure relates to methods of re-oxidizing an antigen-binding protein.

Method of antigen-binding protein production

Antigen binding constructs that bind to desired targets are disclosed, for example antibodies, including antibody fragments (such as scFv and minibodies) that bind to a target molecule, and have one or more of the disclosed hinges are described herein. Methods of use are described herein.

Antigen binding constructs to target molecules

Tent

Growing community of inventors

Los Angeles, CA, United States of America

Chio Mui Chan