Dr. Reddy's Laboratories, Incorporated

Chintakunta Vamseekrishna

Ashok Tehim

Yonghua Gai

Pradip Kumar Sasmal

Vijay Potluri

Hang Zhang

The present invention relates to a series of substituted compounds having the general formula (I), including their stereoisomers and/or their pharmaceutically acceptable salts. wherein R, R, R, R, R, and Rare as defined herein. This invention also relates to methods of making these compounds including intermediates. The compounds of this invention are effective at the kappa (&#x3ba;) opioid receptor (KOR) site. Therefore, the compounds of this invention are useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of central nervous system disorders (CNS), including but not limited to acute and chronic pain, and associated disorders, particularly functioning peripherally at the CNS.

Substituted heterocyclic acetamides as kappa opioid receptor (KOR) agonists

The present invention relates to a series of substituted compounds having the general formula (I), including their stereoisomers and/or their pharmaceutically acceptable salts, wherein R, R, R, R, R, and Rare as defined herein. This invention also relates to methods of making these compounds including intermediates. The compounds of this invention are effective at the kappa (&#x3ba;) opioid receptor (KOR) site. Therefore, the compounds of this invention are useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of central nervous system disorders (CNS), including but not limited to acute and chronic pain, and associated disorders, particularly functioning peripherally at the CNS. 

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Hyderabad Telangana, India

Chintakunta Vamseekrishna