Pharmacyclics, Inc.

Arbor Pharmaceuticals, LLC

Xenoport, Inc.

Ching Wah Chong

Robert Kuehl

Harisha Atluri

Heow Tan

Sami Karaborni

David Juergen Wustrow

Peter Virsik

Chen Mao

Sarina Grace Harris Ma

Mesut Ciper

Stefanie Krenzlin

Peter Robert Prinz Freed

Ryan Mitchell Minikis

Cassandra Shu

Pearl Shwe-Cho Tay

James Francis Hulvat

Alexander Jacob McVey

Peter A Virsik

Sarina Grace Ma

Peter Robert Freed

Improved oral dosage forms of methyl hydrogen fumarate and prodrugs thereof are disclosed. Methods of treating diseases such as multiple sclerosis and psoriasis using such dosage forms are also disclose.

Oral dosage forms of methyl hydrogen fumarate and prodrugs thereof

Described herein are pharmaceutical formulations of Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one. Also disclosed are methods of using the Btk inhibitor, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

Pharmaceutical formulations of a Bruton's tyrosine kinase inhibitor

Pharmaceutical formulations of a bruton's tyrosine kinase inhibitor

Improved oral dosage forms of methyl hydrogen fumarate and prodrugs thereof are disclosed. Methods of treating diseases such as multiple sclerosis and psoriasis using such dosage forms are also disclosed.

Described herein is the Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one, including novel pharmaceutical formulations thereof. Also disclosed are pharmaceutical compositions that include the Btk inhibitor, as well as methods of using the Btk inhibitor, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

Formulations of a bruton's tyrosine kinase inhibitor

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Fremont, CA, United States of America

Ching Wah Chong