Arch Development Corporation

Ching Song

Shutsung Liao

A method of treating a disorder related to a high cholesterol concentration, comprising administering to a subject in need thereof a compound of formula (I): Also disclosed are methods, kits, combinations, and compositions for treating a disorder in a subject where an activator of liver X alpha is indicated, such as in, for example, treating a high cholesterol disease.

Method of treating disorder related to high cholesterol concentration

A compound of formula (I):Each of R, R, R, R, R, R, R, R, R, R, R, R, and R, independently, is hydrogen, halo, alkyl, haloalkyl, hydroxy, amino, carboxyl, oxo, sulfonic acid, or alkyl that is optionally inserted with &#x2014;NH&#x2014;, &#x2014;N(alkyl)&#x2014;, &#x2014;O&#x2014;, &#x2014;S&#x2014;, &#x2014;SO&#x2014;, &#x2014;SO&#x2014;, &#x2014;O&#x2014;SO&#x2014;, &#x2014;SO&#x2014;O&#x2014;, &#x2014;SO&#x2014;O&#x2014;, &#x2014;CO&#x2014;, &#x2014;CO&#x2014;O&#x2014;, &#x2014;O&#x2014;CO&#x2014;, &#x2014;CO&#x2014;NR'&#x2014;, or &#x2014;NR&#x2032;&#x2014;CO&#x2014;; or Rand Rtogether, Rand Rtogether, Rand Rtogether, or Rand Rtogether are eliminated so that a C&#x2550;C bond is formed between the carbons to which they are attached; each of R, R, R, R, and R, independently, is hydrogen, halo, alkyl, haloalkyl, hydroxyalkyl, alkoxy, hydroxy, or amino; n is 0, 1, or 2; A is alkylene, alkenylene, or alkynylene; and each of X, Y, and Z, independently, is alkyl, haloalkyl, &#x2014;OR&#x2032;, &#x2014;SR&#x2032;, &#x2014;NR&#x2032;R&#x2033;, &#x2014;N(OR&#x2032;)R&#x2033;, or &#x2014;N(SR&#x2032;)R&#x2033;; or X and Y together are &#x2550;O, &#x2550;S, or &#x2550;NR&#x2032;; wherein each of R&#x2032; and R&#x2033;, independently, is hydrogen, alkyl, or haloalkyl.

Liver X receptor agonists

Steroid derivatives of this invention interact with nuclear liver X receptor (LXR) and ubiquitous receptor (UR) and can be used to treat a variety of LXR- or UR-mediated disorders.

3,6-dihydroxy-24-amidyl steroid derivatives

The invention relates generally to compositions of and methods for obtaining ubiquitous, nuclear receptor (UR) polypeptides. The invention also relates to polynucleotides encoding UR polypeptides, recombinant host cells and vectors containing UR-encoding polynucleotide sequences, and recombinant UR polypeptides. By way of example, the invention discloses the cloning and functional expression of at least two different UR polypeptides. The invention also includes methods for using the isolated, recombinant receptor polypeptides in assays designed to select substances which interact with UR polypeptides for use in diagnostic, drug design and therapeutic applications.

Growing community of inventors

Chicago, IL, United States of America

Ching Song