Oral Health Australia Pty Ltd

Oral Health Austrailia Pty. Ltd.

Ching Seng Ang

Eric Charles Reynolds

Stuart Geoffrey Dashper

Paul David Veith

Stuart Geoffrey Daspher

The invention is directed to vaccine compositions and methods based onproteins identified to be regulated by haem availability that can be used in the prevention and treatment of periodontal disease. In particular, two specific internalin-likeproteins, namely PG0350 and PG1374 involved in the internalization ofby host cells, the hypothetical protein, PG1019 purported to be a cell surface lipoprotein and the alkyl hydroperoxide reductase protein, PG0618 have been identified as useful targets for the prevention and treatment of periodontal disease.

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The invention provides a composition for use in raising an immune response toin a subject, the composition comprising an amount effective to raise an immune response of at least one polypeptide having an amino acid sequence substantially identical to at least 50 amino acids, or an antigenic or immunogenic portion, of one of the polypeptides corresponding to accession numbers selected from the group consisting of AAQ65462, AAQ65742, AAQ66991, AAQ65561, AAQ66831, AAQ66797, AAQ66469, AAQ66587, AAQ66654, AAQ66977, AAQ65797, AAQ65867, AAQ65868, AAQ65416, AAQ65449, AAQ66051, AAQ66377, AAQ66444, AAQ66538, AAQ67117 and AAQ67118. The invention also provides a method of preventing or treating a subject forinfection comprising administering to the subject a composition of the invention.

Immunology treatment for biofilms

The invention provides a method of preventing, inhibiting or reducing abiofilm in a subject comprising administering to the subject a pharmaceutical composition comprising an inhibiting agent of a polypeptide that reduces or inhibits biofilm formation and/or biofilm development. Also provided are compositions useful in the prevention, inhibition or treatment of periodontal disease orinfection.

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Preston, Australia

Ching Seng Ang