Development Center for Biotechnology

Personal Genomics, Inc.

Ching-Long Hwong

Cheng-Kai Lo

Li-Yen Edward Chang

Ching-Wei Tsai

Chao-Chi Pan

Li-Chi Chang

Lung-Shen Lin

Jyun-Yuan Huang

Ting-Yueh Tsai

Shiuan-Woei Lin Wu

Hsin-Yu Lin

A composition comprising a recombinant DNA polymerase and 3'-esterified nucleotide analogues is provided. The recombinant DNA polymerase includes an amino acid sequence that is at least 90% homology with 9&#xb0; N DNA polymerase (SEQ ID NO: 1), and the recombinant DNA polymerase includes at least two mutations at the positions corresponding to amino acid residues 141 and 143 of the 9&#xb0; N DNA polymerase. A recombinant DNA polymerase is further provided. The recombinant DNA polymerase includes an amino acid sequence that is at least 90% homology with 9&#xb0; N-III DNA polymerase (SEQ ID NO: 3), and the recombinant DNA polymerase includes one or two mutations at the positions corresponding to amino acid residue 480 and 486 of the 9&#xb0; N-III DNA polymerase. A method of performing a polymerization reaction is also provided.

Recombinant DNA polymerase for improved incorporation of nucleotide analogues

Antigenic fragments of human T-lymphotropic virus (HTLV), their fusion proteins with glutathione S-tranferase (GST) or thioredoxin (Thio), and a process for producing the fusion proteins thereof. The antigenic fragment of HTLV comprises the amino acid sequence of SEQ ID Nos: 3 or 4.

Antigenic fragment of human T-lymphotropic virus

The invention relates to nucleic acids containing a nucleotide sequence encoding a polypeptide, the polypeptide having (1) the P2 and P3 regions of a swine vesicular disease virus polyprotein, and (2) an amino acid sequence heterologous to the polyprotein. The invention also includes methods of preparing such nucleic acids (e.g., RNA or DNA expression vectors) and methods of using such nucleic acids to express RNA or protein.

Swine vesicular disease virus expression vectors

The invention provides a novel catalase which is cloned from Bacillus theremoglucosidasius. The invention further provides a process for preparing catalase in high yield, which comprises constructing expression vectors and transformant cells with catalase genes cloned from microorganisms using genetic engineering technology, and obtaining the expression product. The invention also provides a novel recombinant plasmid and a novel transformant cell constructed in the process. In addition, the invention provides a composition for decomposing hydrogen peroxide contained in the residual disinfectant on contact lenses, which comprising the novel catalase of the invention.

Catalase, the gene thereof and composition comprising the same, and

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Kaohsiung, Taiwan

Ching-Long Hwong