National Taiwan University

Ching-jang Huang

Yueh-Hsiung Kuo

Chin Hsu

Bi-Fong Lin

Hong-nong Chou

Ting-ni Huang

Ssu-Ching Wang

Meng-ting Wu

Yi-ping Pai

Kan Ni Lu

Hsin-Sheng Tsay

Emily Chin-Fun Chen

Mei-ling Chang

Chung-Huang Tsai

Yong-Han Hong

The present invention provides a method for enhancing the secretion of GLP-1 of the intestinal endocrine L-cells using a bitter compound, wherein the bitter compound is a cucurbitane-triterpenoid or allyl isothiocyanate. The bitter compound can regulate the secretion of GLP-1, thus is potentially reliable for the development of medicament or healthy victual.

Method for enhancing the secretion of GLP-1 using bitter compounds

The present invention provides a composition for the regulation of Liver X Receptor (LXR) in a cell, and the composition comprises fucoxanthin and its metabolite, fucoxanthinol. The composition of the present invention regulates the transactivation activity of LXR in cell, and antagonizes the transactivation activity of LXR&#x3b1; and/or LXR&#x3b2; induced by LXR agonists. In other aspects, the present invention also provides a method of regulating a liver X receptor. The composition for the regulation of liver X receptor and the application thereof according to the present invention can regulate the transactivation activity of LXR in cell, and can further be used as alternatives for LXR agonist or antagonist, or supplements, for enhancing LXR-related symptoms.

Composition for regulation of liver X receptor

Disclosed is a cucurbitane-triterpenoid compound for activating estrogen receptor activity, and a pharmaceutical composition, use and preparation method thereof. The cucurbitane-triterpenoid compound is presented as formula (I): wherein a single bond or a double bond is formed between C5 and C10, and a single bond or a double bond is fromed between C8 and C9; when a single bond is formed between C5 and C10, the Ris oxygen; while a single bond is formed between C8 and C9, Ris carbonyl group (&#x2014;C&#x2550;O), methyl hydroxyl group (&#x2014;CH(OH)), methyl ketone or methyl dimethoxy group (&#x2014;CH(OCH)); and wherein while Ris oxygen (&#x2014;O&#x2014;) and Ris carbonyl group (&#x2014;C&#x2550;O) or methyl hydroxyl group (&#x2014;CH(OH)), a single bond is formed between R(&#x2014;O&#x2014;) and C19 of Rsuch that Rand Rare formed tetrahydro-2H-pyran-2-one or hemiacetal ring.

Cucurbitane-triterpenoid compounds, pharmaceutical composition, use and preparation method thereof

The present invention provides a mitochondria regulator composition, which comprises a wild bitter gourd extract. The mitochondria regulator composition can regulate the function of mitochondria in a cell, and further regulate the efficiency of adaptive thermogenesis and energy expenditure in a cell.

Mitochondria regulator composition

The present invention relates to compounds having estrogenic activity selected from the group consisting of Loliolide, (4S,6S)-4-Hydroxy-6-nonadecyl-tetrahydro-pyran-2-one, (4R,6S)-4-Hydroxy-6-nonadecyl-tetrahydro-pyran-2-one and analogues thereof. The compounds of the present invention are selective estrogen receptor modulator, which can selectively activate ER&#x3b2; and simultaneously express high estrogenic activity, and also can be applied as medical or food compositions to improve estrogen deficiency-related symptoms.

Estrogenic-active compounds and application thereof

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Taipei, Taiwan

Ching-jang Huang