The General Hospital Corporation

Ching-Hsuan Tung

Ralph Weissleder

Alexei A Bogdanov

Lee Josephson

Umar Mahmood

Alexei Bogdanov

An intramolecularly-quenched, near infrared fluorescence probe that emits substantial fluorescence only after interaction with a target tissue (i.e., activation) is disclosed. The probe includes a polymeric backbone and a plurality of near infrared fluorochromes covalently linked to the backbone at fluorescence-quenching interaction-permissive positions separable by enzymatic cleavage at fluorescence activation sites. The probe optionally includes protective chains or fluorochrome spacers, or both. Also disclosed are methods of using the intramolecularly-quenched, near infrared fluorescence probes for in vivo optical imaging.

Intramolecularly-quenched near infrared fluorescent probes

Intramolecularly-quenched near infrared flourescent probes

Nucleic acid-imaging compositions and methods for noninvasive imaging of a nucleic acid introduced into somatic tissues of an animal or human are disclosed. The noninvasive imaging enables quantitative assessment of the biodistribution of the introduced nucleic acid. The disclosed imaging compounds include a base-binding moiety, a phosphate-binding moiety, and a metal-binding moiety. A chelated metal is non-invasively detected for imaging by radioactivity or magnetic resonance.

Noninvasive imaging of nucleic acid vectors

Growing community of inventors

Natick, MA, United States of America

Ching-Hsuan Tung