Animal Technology Institute Taiwan

Animal Technology Institute

Ching-Fu Tu

Chun-Jean Lee

Wen-Chuan Lee

Ming-Yu Chen

Jang-Ming Lee

Jyh-Hung Lin

San-Yuan Huang

Kimiyoshi Tsuji

Lin-Lin Ho

Kuei-Feng Huang

Hao-Chih Tai

Chi-Kai Yang

Bor-Show Tzang

Ming-Shing Liu

The invention provides a transgenic animal carrying two transgenes, one encoding a human decay accelerating factor (hDAF) and the other encoding a human heme oxygenase-1 (hHO)-1, which are useful for providing cells, tissues or organs therefrom for xenotransplantation.

Transgenic pigs carrying both hHO-1 and hDAF transgenes for xenotransplantation

The invention provides a transgenic pig having incorporated into its genome a HSP70 gene or fragment thereof, whereby the transgenic pig overexpresses HSP70. The transgenic pig of the invention can be used in the production of HSP in large quantities, as a xenograft source for transplantation and as an animal model close to human for illustrating the protective roles of HSP. Furthermore, the transgenic pig of the invention has a better meat quality and exhibits an increased growth rate and a reduced backfat thickness.

Transgenic pig containing heat shock protein 70 transgene

The invention provides a transgenic swine having a transgene encoding a human HLA-DQ or HLA-DR protein, and the swine cells thereof. The invention also provides a graft derived from the transgenic swine, in particular a graft-organ or a graft-tissue, which is useful for grafting into a human recipient.

Transgenic swine having HLA-D gene, swine cells thereof and xenografts therefrom

Growing community of inventors

Miaoli Hsien, Taiwan

Ching-Fu Tu