Merck + Co., Inc.

University of California

Ching C Wang

Michael H Fisher

Irwin D Kuntz

Arthur A Patchett

A Geoffrey Skillman

Connie M Oshiro

Paul R Ortiz De Montellano

John Somoza

Jon P Page

Ronaldus Marcellus Knegtel

Narsimha R Munagala

Nancy J Dick

Alex M Aronov

The use of certain heterocyclic derivatives for treating parasitic protozoa infections in mammals, in particular bovine trichomoniasis and giardiasis, is disclosed.

Substituted 4-phthalimidocarboxanilides as inhibitors of purine salvage phosphoribosyltransferases

Heterocyclic derivatives as inhibitors of purine salvage

Fluorouracil and emimycin are useful in the treatment of giardiasis and trichomoniasis.

Treatment of giardiasis and trichomoniasis

1-Substituted-4(1H)-pyridinone hydrazones, known as effective anti-coccidial agents, are useful as potent anti-giardiasis and anti-trichomoniasis agents.

1-Substituted-4 (1H)-pyridinone hydrazones active against Giardia

Substituted-1-(cinnamylideneamino)-3-benzylideneaminoguanidines, known as effective anti-coccidial agents, are useful as potent anti-giardiasis and anti-trichomoniasis agents.

Substituted 1-(cinnamylideneamino)-3-benzyli-deneaminoguanidines active

Benzylidene aminoguanidene derivatives, known as effective anti-coccidial agents, are useful as potent anti-giardiasis and anti-trichomoniasis agents.

Method of treating giardiasis and trichomoniasis

Emimycin, 1,2-dihydro-1-(2-deoxy-.beta.-D-erythropentofuranosyl)-2-oxypyrazine-4-oxi de and the novel compounds 1,2-dihydro-1-(2-deoxy-3,5-di-O-loweralkanoyl-.alpha.-D-erythro-pentofuran osyl)-2-oxopyrazine 4-oxide are active anticoccidial agents. Preferably, the alkanoyl group of the novel compounds contain up to six carbon atoms. The compounds are included in compositions useful for the prevention and treatment of coccidiosis in poultry.

Growing community of inventors

San Francisco, CA, United States of America

Ching C Wang