W. L. Gore & Associates, Inc.

Supercritical Fluid Technologies, Inc.

Chinedu David Chikwem

Brian Jeffrey Waibel

Kenneth Joseph James

Wai Poon

Kim Ferrara

Kenneth Richard Krewson

Ryder William Pingry

Daniel Alan Brisach

Curtis Ebersold

Kim Ferrera

Curtis B Ebersold

Christopher Joseph Mcwilliams

Systems and methods of filtering with filter assemblies including a frame having a header structure, an end cap structure, and a plurality of side plates coupling the header structure to the end cap structure are provided. The filter pleated media may include an upstream surface and a downstream surface opposite the upstream surface in a direction of flow through the filter assembly, and the filter pleated media may include a pleated configuration. The filter assemblies may further include a support member coupled to a portion of the frame and along at least one of the upstream surface or the downstream surface of the filter pleated media. The support member may at least partially penetrate the pleated configuration and extend into a pleat of the pleated configuration of the filter pleat media.

Support members for filter pleated media

Provided is a chiller and system that may be utilized in a supercritical fluid chromatography method, wherein a non-polar solvent may replace a portion or all of a polar solvent for the purpose of separating or extracting desired sample molecules from a combined sample/solvent stream. The system may reduce the amount of polar solvent necessary for chromatographic separation and/or extraction of desired samples. The system may incorporate a supercritical fluid chiller, a supercritical fluid pressure-equalizing vessel and a supercritical fluid cyclonic separator. The supercritical fluid chiller allows for efficient and consistent pumping of liquid-phase gases employing off-the-shelf HPLC pumps. The pressure equalizing vessel allows the use of off-the-shelf HPLC column cartridges. The system may further incorporate the use of one or more disposable cartridges containing silica gel or other suitable medium. The system may also utilize an open loop cooling circuit using fluids with a positive Joule-Thompson coefficient.

Cooling loop with a supercritical fluid system using compressed refrigerant fluid flow with a positive Joule-Thomson coefficient

Provided is a supercritical fluid chromatography system, and components comprising such a system, including one or more of a supercritical fluid chiller, a supercritical fluid pressure-equalizing vessel, and a supercritical fluid cyclonic separator. The supercritical fluid chiller and the use of the chiller allow efficient and consistent pumping of liquid-phase gases employing off-the-shelf HPLC pumps in the supercritical chromatography system using liquid-phase gas mobile phase. The pressure equalizing vessel allows the use of off the shelf HPLC column cartridges in the supercritical chromatography system. The cyclonic separator efficiently and effectively allows for separation of sample molecules from a liquid phase or gas phase stream of a supercritical fluid.

Supercritical fluid chromatography system

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Wilmington, DE, United States of America

Chinedu David Chikwem