Chiron Corporation

Novartis Vaccines & Diagnostics, Gmbh

Schering Corporation

Chin-Yi Huang

Ronald N Zuckermann

Tetsuo Uno

John E Murphy

Toshihiko Takeuchi

Linda Masat

Bao-lu Chen

Sumant Ramachandra

Chao Bai Huang

Walter Robert Bishop

Seema Kantak

Disclosed herein are fully human antibodies and antigen-binding fragments thereof that specifically bind human VEGF and inhibit VEGF binding to VEGF-R1 and VEGF-R2, and therefore inhibit VEGF signaling. The antibodies and antigen-binding fragments disclosed herein may be used, for example, to treat angiogenesis and conditions associated with angiogenesis both in vivo and in vitro.

Fully human anti-VEGF antibodies and methods of using

Stabilized aqueous compositions of tissue factor pathway inhibitor (TFPI) or TFPI variants comprise a solubilizing agent, an antioxidant, and a buffer. The combination of a solubilizing agent and an antioxidant can lead to a significant improvement in the storage life of TFPI or TFPI variant compositions. The solubilizing agent and antioxidant substantially counteract the effects of TFPI or TFPI variant degradation through aggregation and oxidation.

Stabilized compositions comprising tissue factor pathway inhibitor protein or tissue factor pathway inhibitor variant proteins

In accordance with the present invention, there are provided lipid-conjugated polyamide compounds and related compositions and methods thereof. Lipid-conjugated polyamide compounds of the present invention are particularly useful as vehicles for delivering biologically active agents to a target site. In particular, the invention compounds are effective at facilitating the delivery of polynucleotides to cells. The present invention also provides a method for producing stable formulations of polynucleotides complexed with a delivery vehicle.

Lipid-conjugated polyamide compounds

Method of complexing a nucleic acid with a lipid-conjugated polyamide

Lipid-conjugated polyamide compounds and related compositions and methods thereof

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Fremont, CA, United States of America

Chin-Yi Huang