The University of Chicago

Arch Development Corporation

National Health Research Institutes

Univ. of Chicago Development Corp. Argonne National Laboratories

Chin-Tu Chen

Qingguo Xie

Brian Popko

Chien-min Kao

Pedro Brugarolas

Daniel Appelbaum

Chien-Min Kao

Zekai Hsiau

Jeffrey W Elam

Kunio Doi

Maryellen L Giger

Anil U Mane

Ralph R Weichselbaum

Xiaochuan Pan

Henry J Frisch

Miles N Wernick

Charles A Pelizzari

Fukun Tang

Samuel Armato

Jean-Francois Genat

Heejong Kim

Samuel Hellman

Hervé Grabas

The present disclosure provides novel compounds, including compounds that bind to potassium channels, methods for their manufacture, and methods for their use, including their use to diagnose and/or assess traumatic brain injury and use to treat demyelinating diseases, and/or in vivo imaging of the central nervous system, and to diagnose and/or assess the progression of MS or other diseases.

Use of fluorinated derivatives of 4-aminopyridine in therapeutics and medical imaging

The present disclosure provides novel compounds, including compounds that bind to potassium channels, methods for their manufacture, and methods for their use, including their use to diagnose and/or assess traumatic brain injury and use to treat dymeylinating diseases, and/or in vivo imaging of the central nervous system, and to diagnose and/or assess the progression of MS or other diseases.

Large-area, flat-panel photo-detectors with sub-nanosecond time resolution based on microchannel plates are provided. The large-area, flat-panel photo-detectors enable the economic construction of sampling calorimeters with, for example, enhanced capability to measure local energy deposition, depth-of-interaction, time-of-flight, and/or directionality of showers. In certain embodiments, sub-nanosecond timing resolution supplies correlated position and time measurements over large areas. The use of thin flat-panel viewing radiators on both sides of a radiation-creating medium allows simultaneous measurement of Cherenkov and scintillation radiation in each layer of the calorimeter. The detectors may be used in a variety of applications including, for example, medical imaging, security, and particle and nuclear physics.

Use of flat panel microchannel photomultipliers in sampling calorimeters with timing

A device and method used in the high resolution Positron Emission Tomography (PET) systems for digitizing radiation events for a scintillation camera and a data acquisition system. The device comprises a scintillation digitizer, including a plurality of comparators and amplifiers, two ADCs, and an analyzer for resolving the digital values of radiation events. The method comprises comparing a plurality of analog electric pulses generated upon radiation event detections with a reference voltage corresponding to an energy level of interest, amplifying all of the signals with two groups of coefficients, summing the two groups of amplified signals, digitizing the summed signals, and analyzing the digitized sums to determine digital values corresponding to a plurality of the radiation events.

Device and method for digitizing pet radiation events

In some embodiments, an image-guided radiotherapy apparatus and method is provided in which a radiotherapy radiation source and a gamma ray photon imaging device are positioned with respect to a patient area so that a patient can be treated by a beam emitted from the radiotherapy apparatus and can have images taken by the gamma ray photon imaging device. Radiotherapy treatment and imaging can be performed substantially simultaneously and/or can be performed without moving the patient in some embodiments. The gamma ray photon imaging device can be coupled and movable with respect to any part of a building structure, can be located on a portable frame movable to and from the radiotherapy radiation source and patient, or can take other forms. In some embodiments, the gamma ray photon imaging device can be used for imaging in connection with other types of medical interventions.

Image-guided medical intervention apparatus and method

A device and method used in high resolution positron emission tomography (PET) systems for digitizing gamma ray energy and characterizing peak time and decay time constant, models a voltage pulse generated upon a PET event detection as a fast linearly rising edge followed by a slower exponential decay. The model includes parameters of the voltage pulse that are relevant for PET event detection including a decay constant, a peak voltage value, and a peak time, which are determined from time interval measurements of the voltage pulse. The time interval measurements are made using comparators and counters in an exemplary electronic implementation.

Device and method for digitizing gamma ray energy and characterizing peak time and decay time constant without the use of ADC

A method and apparatus are provided for reconstructing images from data obtained from scintillation events occurring within a projection space of a depth-of-interaction positron emission tomography system. The method includes the steps of identifying a segment of each depth-of-interaction detector of respective pairs of depth-of-interaction detectors detecting the scintillation-events of the data obtained within the projection space and estimating a set of sinograms from the data based upon a set of depth-independent point spread functions of the identified segments of the respective pairs of depth-of-interaction detectors.

Accurate image reconstruction for DOI-PET system

A method and system for the computerized registration of radionuclide images with radiographic images, including generating image data from radiographic and radionuclide images of the thorax. Techniques include contouring the lung regions in each type of chest image, scaling and registration of the contours based on location of lung apices, and superimposition after appropriate shifting of the images. Specific applications are given for the automated registration of radionuclide lungs scans with chest radiographs. The method in the example given yields a system that spatially registers and correlates digitized chest radiographs with V/Q scans in order to correlate V/Q functional information with the greater structural detail of chest radiographs. Final output could be the computer-determined contours from each type of image superimposed on any of the original images, or superimposition of the radionuclide image data, which contains high activity, onto the radiographic chest image.

Automated method and system for the alignment and correlation of images

A method and system for improving signal recovery for tomographic-type detection systems is disclosed which reduces the effect of blurring by obtaining a spatial response function for a plurality of selected detectors and moving the detectors to various positions at various times such that at least two tomographic measurements are taken of substantially the same signal when the object and detection means are at different relative positions. The measurements are then represented as a set of linear equations wherein elements of the response function become weighting factors for corresponding unknown tomographic signal elements. The unknown tomographic signal elements are then estimated by solving the set of linear equations. The tomographic signal elements may then be used as data in projection profiles to generate projection matrices or images directly.

Growing community of inventors

Chicago, IL, United States of America

Chin-Tu Chen