Industrial Technology Research Institute

Tsinghua University

Chin-Fu Chen

Chun-Jen Liao

Tsai-Yu Lin

Hsin-Hsin Shen

Ya-Jen Yu

Shao-Jen Yeh

Yu-Ju Lin

Yu-Bing Liou

Yuan-Chia Chang

Ken-Yuan Chang

Meng-Yow Hsieh

Shan-Chang Chueh

Pei Kan

Shian-Yih Wang

Shu-Fang Chiang

Li-Hsin Lin

Rung-Jiun Gau

Ming-Fa Hsieh

Ming-Cheng Shih

Po-Liang Lai

Yu-Shih Weng

Hsiu-Hua Huang

Ying-Hsueh Chao

Miao-Tzu Chen

Wen-Hwa Lu

Chih-Bing Hung

Jui-Hsiang Chen

Yu-Chi Wang

Shwin-Chung Wong

Yuan-Hung Hsu

Wei-Lin Yu

Hsuen-Tseng Chang

Chin-Yu Lin

Huey-Min Lai

Yung-chih Wu

Sen-Lu Chen

Pei-Shan Li

Wei-Yuan Hsu

Chung-Nun Chen

Hsin-hsin Shen

Hsuen-Tseng Cha'ng

Yure-Ru Lin

Tsung-Yi Mou

Yu-Yen Jan

Kuei-Hung Wu

Chun-Hui Chang

Wen-Fu Lee

Yung Feng Chang

Yung Chih Wu

The present disclosure provides a hydrogel composition including: a hydrogel having a structure represented by Formula (I) or Formula (II) shown as follows: A-B-BOX-B-A, Formula (I); B-A-B-(BOX-BAB)n-BOX-B-A-B, Formula (II), wherein, A is a hydrophilic polyethylene glycol polymer, B is a hydrophobic polyester polymer, BOX is a bifunctional group monomer of 2,2'-Bis(2-oxazoline) for coupling di-block of A-B or tri-block of B-A-B, and n is an integer greater than or equal to 0; and an anti-adhesion additive, wherein the anti-adhesion additive comprises a carbohydrate, a nitrogen-containing cyclic compound, a polymer or a combination thereof.

Hydrogel composition and method for using the same

The present invention relates to a rapidly removable thermal connector including a retainer and a clamper. The retainer has a first wedge connected with a convexity of a first two-convexity tenon and a second wedge. At the outer end of the first wedge has a mortise to allocate a convexity of the first two-convexity tenon; at the inner end of the second wedge has a mortise to allocate a convexity of a second two-convexity tenon. The clamper is used to hold the retainer. At the interior of the outer end of the clamper has a movable unit which is connected to the clamper with a bolt at one end and has a vertical concavity at the other end to match the first convexity of the first two-convexity tenon. At the interior of the inner end of the clamper has a mortise which allocates the fourth convexity of the second two-convexity tenon. The third convexity of the second two-convexity tenon is connected to a mortise at the inner end of the second wedge.

Quick detachable thermal connector

A bioresorbable porous film, including a blend mixture of polylactic acid and at least two kinds of polyethylene glycol, wherein the at least two kinds of polyethylene glycol include a first polyethylene glycol, which is in a solid form under ambient temperature and atmospheric pressure, and a second polyethylene glycol, which is in a liquid form under ambient temperature and atmospheric pressure is provided. The film has a porosity of 10%-90%.

Bioresorbable porous film

The disclosure provides a solid form and a method for preparing the same. The solid form consists essentially of a biodegradable copolymer and an amide-containing compound. The biodegradable copolymer is semi-crystalline due to the dipole-dipole interaction between the biodegradable copolymer and the urea. The method for preparing the above solid form includes: dissolving a biodegradable copolymer and an amide-containing compound in water at a first temperature, obtaining a solution; cooling the solution at a second temperature to form a solid mixture; and the solid mixture is subjected to a freeze-drying process at a third temperature.

Solid form and method for preparing the same

An amphiphilic block copolymer is disclosed. The amphiphilic block copolymer includes one or more hydrophilic polymers, one or more hydrophobic polymer, and one or more zwitterions. The invention also provides a nanoparticle and carrier including the amphiphilic block copolymer for delivery of water insoluble drugs, growth factors, genes, or water insoluble cosmetic substances.

Amphiphilic block copolymers and nanoparticles comprising the same

In a general aspect, an apparatus for washing biological material is provided which includes an outer sleeve, and an inner sleeve disposed within the outer sleeve. The outer sleeve has an open end for receiving the biological material, and an opposed closed end. The inner sleeve is detachably and slidably positioned within the outer sleeve, and includes a first port for receiving and dispensing washing liquid, a second port defining a liquid flow path between an interior of the inner sleeve and an interior of the outer sleeve, and a filter disposed in the second port. The filter allows passage of washing liquid but not passage of the biological material therethrough. A chamber, formed between the filter and the closed end of the outer sleeve, is configured to permit flow of washing liquid via the filter while retaining the biological material therein.

Apparatus and method for washing biological material

The disclosed is a biodegradable copolymer, an amphiphilic diblock copolymer, composed of a hydrophilic segment and a hydrophobic segment. The hydrophilic segment is an endcapped PEG or derivatives thereof. The hydrophilic segment is a random polymer polymerized of lactone or cyclic C-Cmolecule and lactic acid/glycolic acid. There is no coupling agent between the hydrophilic and hydrophobic segments, and the biodegradable copolymer is formed by one-pot ring-opening polymerization. The biodegradable copolymer can be dissolved in water to form a thermosensitive material having a phase transfer temperature of 25 to 50&#xb0; C., thereby being applied to biological activity factor delivery, tissue engineering, cell culture and biological glue.

Biodegradable copolymer and thermosensitive material

Biodegradable copolymer hydrogels are provided. The biodegradable copolymer hydrogels have a structure of Formula (I) or Formula (II)A-B&#x2014;BOX&#x2014;B-A&#x2003;&#x2003;Formula (I)B-A-B&#x2014;(BOX&#x2014;B-A-B)-BOX&#x2014;B-A-B&#x2003;&#x2003;Formula (II),

Biodegradable copolymer hydrogels

A cell culture apparatus and a method for fabricating the cell culture apparatus are disclosed, the method comprises forming at least one fillister on a biomaterial composite layer by photolithography, wherein the biomaterial composite layer contains two gel materials. One is a bio-compatible hydrogel composition having various weight ratio of: 2-hydroxyethylmathacrylate (HEMA), bisphenol A and glycidyl methacrylate (bis-GMA), triethylene glycol dimethacrylate (TEGDMA), r-methacryloxypropyl trimethoxysilane (MAPTMS), &#x3b1;,&#x3b1;-diethoxyacetophenone (DEAP), and the other one is a photo-sensitive silica gel composition.

Cell culture apparatus and method of fabricating the apparatus

An amphiphilic block copolymer. The amphiphilic block copolymer includes one or more hydrophilic polymers, one or more hydrophobic polymer, and one or more zwitterions. The invention also provides a nano particle and carrier comprising the amhpiphilic block copolymer for delivery of water-insoluble drugs, growth factors, genes, or cosmetic substances.

Amphiphilic block copolymers and nano particles comprising the same

A porous chamber for tissue culture in vitro. The porous chamber includes a main body made of porous biologically absorbable polymer material, comprising an inner surface surrounding a hollow cavity, the hollow cavity having an aperture opened at an upper surface of the main body, wherein the aperture is communicated with outside of the main body for seeding tissue blocks in the hollow cavity, and an upper cover passing through the upper surface of the main body to seal the aperture to prevent the tissue blocks from outflowing.

Porous chamber for tissue culture in vivo

A cell culture apparatus and a method for fabricating the cell culture apparatus are disclosed, the method comprises forming at least one fillister on a biomaterial composite layer by photolithography, wherein the biomaterial composite layer contains two gel materials. One is a bio-compatible hydrogel composition having various weight ratio of: 2-hydroxyethylmathacrylate (HEMA), bisphenolA and glycidyl methacrylate (bis-GMA), triethylene glycol dimethacrylate (TEGDMA), r-methacryloxypropyl trimethoxysilane (MAPTMS), &#x3b1;,&#x3b1;-diethoxyacetophenone (DEAP), and the other one is a photo-sensitive silica gel composition.

Hydrogel composition for cell culture apparatus

The present invention provides method and carrier for culturing multi-layered tissue in vitro, wherein few amounts of tissue blocks and cells are positioned within a porous multi-layer carrier consisting of a cavity structure. By taking advantage of the structure of the carrier, tissue blocks and cells are separated into different layers according to their sizes, and incubated in vitro to reconstruct a multi-layered tissue for tissue repair.

Method and carrier for culturing multi-layer tissue in vitro

A process for producing porous polymer material. The method combines a polymer and water-soluble granules to form a mixture. The mixture is placed into a mold; the surface of the polymer is dissolved to cause cohesion and form a polymer structure having water-soluble granules dispersed within, and water is introduced into the inner part of the polymer structure so that the polymer is solidified and water-soluble granules are washed out to obtain a porous polymer material. According to the invention, single or multiple layers of porous polymer material with different apertures, porosities, or made with different materials, are obtained by combining different polymer materials and water-soluble granules having different particle sizes in different weight ratios.

Process for producing porous polymer materials

Growing community of inventors

Taipei, Taiwan

Chin-Fu Chen