Development Center for Biotechnology

Chin-Fen Lee

Shan-Shue Wang

Ji-Wang Chern

Shyh-Fong Chen

Shan-Yen Chou

Shih-Chung Hsu

Chia-Lin J Wang

Jaw-Yuh Chiu

Feng-Wen Yeng

Yu-Ling Leu

Wei-Kun Yin

A compound of the formula: ##STR1## wherein X is arylene, heteroarylene, fused arylene, fused heteroarylene, or deleted; Y is sulfonyl, --O--, or deleted; R.sub.1 is aryl, heteroaryl, fused aryl, or fused heteroaryl; R.sub.2 is H, lower alkyl, lower alkoxy, halo, nitro, cyano, haloalkyl, hydroxyl, carboxyl, amido, amino, or aminoalkyl; or a salt thereof are disclosed. Also disclosed are a pharmaceutical composition which contains an excipient and an effective amount of a compound of the above formula and a method of treating cancer which involves the administration of an effective amount of such a compound to a patient in need thereof.

Sulfonyl-N-hydroxyguanidine derivatives

A series of novel polyamine-linked acridine dimers and derivatives thereof are described. The polyamine-linked acridine dimers and derivatives are potential anti-cancer agents.

Polyamine-linked acridine dimers

The invention relates to novel compounds of formula (I) ##STR1## wherein R.sub.1 represents hydrogen, hydroxy or alkoxy;

Antiatherosclerosis agents for lipid-lowering and antiperoxidative

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Keelung, Taiwan

Chin-Fen Lee