National Institute of Advanced Industrial Science and Technology

Chikashi Nakamura

Jun Miyake

Sang-Mok Chang

Seong-Hun Song

Takaaki Arai

A method and apparatus for discriminating and separating only specific cells in cell samples is provided. The cell separation operation includes inserting a needle-shaped body, on which a substance that selectively binds to a marker substance within each target cell has been immobilized, into each of the cell samples on a substrate, thereby causing the marker substance within each target cell in the cell samples to bind to the needle-shaped body through the substance that selectively binds to the marker substance, and then, pulling up the needle-shaped body. The binding force between the needle-shaped body and each target cell when the marker substance within each target cell has bound to the needle-shaped body is made greater than an adhesion force of each of the cell samples to the substrate, so that only target cells each containing the marker substance are pulled up and separated from the substrate.

Method of separating cells and separation apparatus

The invention relates to a method for detecting a low molecular weight compound in a solution which utilizes a quartz resonator and which comprises capturing a low molecular weight compound between an adsorptive film (A) for a low molecular weight compound provided on the surface of a quartz resonator and an adsorptive film (A) for a low molecular weight compound provided on the surface of a signal enhancing material and comprises detecting the shift in frequency of the quartz resonator before and after the capture.

Growing community of inventors

Tsukuba, Japan

Chikashi Nakamura