Phg Corporation

Chikara Otsuki

Masao Tanihara

Hisao Kinoshita

Hiroshi Mikami

A process for producing a polypeptide, by reacting a peptide component (A) represented by formula (1) below with a peptide component (B) represented by formula (2) below and optionally a compound (C) represented by formula (3) below, to obtain said polypeptide:

Polypeptide and process for producing the same

The invention provides for a polypeptide, which is useful as a biomaterial and free from infection. The polypeptide comprises a peptide unit of formula (1), and optionally one or more units of formulae (2) to (3): (1) [&#x2014;(OC&#x2014;(CH&#x2014;CO)-(Pro-Y-Gly)-]; (2) [&#x2014;(OC&#x2014;(CH)&#x2014;CO)-(Z)-]; and (3) [&#x2014;HN&#x2014;R&#x2014;NH&#x2014;], wherein 'm' is 1-18 , 'p' and &#x201c;q&#x201d; are identical or different, and each is 0 or 1 , &#x201c;Y&#x201d; is Pro or Hyp, and &#x201c;n&#x201d;1-20 ; &#x201c;Z&#x201d; is a peptide chain comprising 1-10 amino acids, &#x201c;r&#x201d;1-20 , and &#x201c;R&#x201d; is a linear or branched alkylene group; the molar ratio of &#x201c;a&#x201d; to &#x201c;b&#x201d;[a/b] is 100/0 to 30/70 ; when p=1 and q=0, c=a, when p=0 and q=1, c=b, when p=1 and q=1, c=a+b, and when p=0 and q=0, c=0; and the polypeptide shows a peak of molecular weight in a range from 1&#xd7;10to 100&#xd7;10in the molecular weight distribution.

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Ikoma, Japan

Chikara Otsuki