Kyowa Hakko Kogyo Co., Ltd.

Cephalon, Inc.

Other

Kyowa Hakko Kirin Co., Limited

Fujifilm Corporation

Fuji Photo Film Company, Limited

Kyowa Hakko Kogyo

Chikara Murakata

Shiro Akinaga

Hiromitsu Saito

Nobuyoshi Amishiro

Yukimasa Shiotsu

Fumihiko Kanai

Nicola T Neff

Marcie A Glicksman

Tatsuya Tamaoki

Pui-Kai Li

Yoji Ino

Takeshi Takahashi

Yoshinori Yamashita

James C Kauer

Michael E Lewis

Yuzuru Matsuda

Ryuichiro Nakai

Jill M Roberts-Lewis

Yutaka Saitoh

Masami Okabe

Masami Kaneko

Tadakazu Akiyama

Mayumi Miyata

Robert L Hudkins

Yutaka Kanda

Masaji Kasai

Hiroshi Kase

Tadashi Ashizawa

Yoshihisa Ohta

Shiro Soga

Harumi Ogawa

Kazuhiko Kato

Takako Shiraki

Hiroshi Sano

Hiroyuki Yamaguchi

Hiroyuki Ishida

Yutaka Saito

Mitsuru Takahashi

Koji Yamada

Makoto Morimoto

John P Mallamo

Eiji Kobayashi

Hitoshi Arai

Shun-ichi Ikeda

Craig A Dionne

Patricia C Contreras

Taisuke Nakata

Masami Hamano

David P Rotella

Junichi Watanabe

Akira Sato

Isao Kawamoto

Tadashi Hirata

Katsushige Gomi

Shunji Ichikawa

Katsuichi Shuto

Shigeto Kitamura

Kenichi Mochida

Toru Yasuzawa

Takao Iida

Keiichi Takahashi

Takehiro Ogasa

Ikuo Matsukuma

Yuichi Fukuda

Masayuki Teranishi

Hideaki Kusaka

Satoshi Nakanishi

Tsutomu Agatsuma

Yoshiaki Masuda

Shinji Tomioka

Akira Mihara

Yukiteru Mimura

Shigeo Katsumata

Junichiro Yamamoto

Kinya Yamashita

Takashi Kuwabara

Reiko Tanaka

Yushi Kitamura

Shingo Kakita

Yuichi Takahashi

Toshimitsu Takiguchi

Hisashi Tagaya

Masahiko Kinugawa

Rieko Tanaka

Eiichi Fuse

Yoji Ikuina

Takako Iida

Kazuyo Sugiyama

Emi Shimoike

Kazuyuki Iwashashi

Toshiyuki Atsumi

Hiroko Takahashi

Jun Funahashi

Kozue Muramatsu

Kenichi Yasoshima

A therapeutic and/or prophylactic agent for restenosis, which comprises a thiadiazoline derivative represented by the general formula (0), or a pharmaceutically acceptable salt thereof: [wherein, n represents an integer of 1 to 3, Rrepresents aryl, &#x2014;NRCONR(wherein Rrepresents a hydrogen atom or the like, and Rrepresents lower alkyl or the like) or the like, Rrepresents lower alkyl, Rrepresents a hydrogen atom or the like, and Rrepresents aryl or the like].

Therapeutic agent for restenosis

(wherein Rand Rare the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkynyl, substituted or unsubstituted lower alkenyl, or the like; Rrepresents a substituted or unsubstituted heterocyclic group, substituted or unsubstituted aryl, or the like; Rrepresents &#x2014;C(&#x2550;W)Ror the like; Rrepresents a hydrogen atom, &#x2014;C(&#x2550;W)R, or the like) Antitumor agents which comprises a thiadiazoline derivative represented by the aforementioned general formula (I) or a pharmacologically acceptable salt thereof as an active ingredient are provided. 

Thiadiazoline derivative

(wherein Rand Rare the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkynyl, substituted or unsubstituted lower alkenyl, or the like; Rrepresents a substituted or unsubstituted heterocyclic group, substituted or unsubstituted aryl, or the like; Rrepresents &#x2014;C(&#x2550;W)Ror the like; Rrepresents a hydrogen atom, &#x2014;C(&#x2550;W)R, or the like) Antitumor agents which comprises a thiadiazoline derivative represented by the aforementioned general formula (I) or a pharmacologically acceptable salt thereof as an active ingredient are provided.

The present invention provides a nitrogen-containing heterocyclic compound represented by formula (I): {wherein W represents a nitrogen atom or &#x2014;CH&#x2014;; 

Nitrogen-containing heterocyclic compound

Provided is steroid sulfatase inhibitors comprising, as the active ingredient, an estra-1,3,5(10)-triene derivative which is represented by formula (I):{wherein Rand Rare the same or different and represent a hydrogen atom, a lower alkyl group or, etc.; Rrepresents a hydrogen atom etc.; Rrepresents a hydrogen atom etc.; Rrepresents a hydrogen atom etc.; Rrepresents a cyano group, an amino group, COR(wherein Rrepresents a substituted lower alkyl group etc.), a substituted or unsubstituted aryl group, a substituted or unsubstituted heterocyclic group, etc}, or pharmaceutically acceptable salts thereof.

Estra-1,3,5(10)-triene derivatives

Disclosed herein are selected indolocarbazole derivatives which are represented by the general formula: The compounds are useful for enhancing the function and/or survival of a trophic factor responsive cell. They inhibit interleukin-2 production and have immunosuppressive activity.

Selected derivatives of K-252a

Staurosporin derivatives

Estra-1,3,5(10),16-tetraene derivatives

Radicicol derivatives

Novel sulfatase inhibitor compounds useful in the treatment of estrogen dependent illnesses are disclosed. These compounds generally comprise a steroid nucleus substituted at the C17 position. Methods for synthesizing these compounds and using them in the therapeutic and/or prophylactic treatment of a patient are also disclosed.

Steroid sulfatase inhibitors and methods for making and using the same

Radioicol derivatives represented by the following formula (I) having tyrosine kinase inhibition activity or pharmacologically acceptable salts thereof:

Disclosed herein are selected indolocarbazole derivatives which are represented by the general formula:

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Shizuoka, Japan

Chikara Murakata