Hoffmann-la Roche Inc.

Chikara Miyamoto

Akiko Fujiwara

Mitsuhiko Fujiwara

Toru Okuda

The invention relates to a process for producing 1.alpha.-hydroxydehydroepiandrosterone by fermenting or reacting dehydroepiandrosterone or a derivative thereof with microorganisms of the species Penicillium oxalicum or Aspergillus terreus or mycelium or extracts therefrom obtained when the microorganisms are in a stationary phase of growth. The invention process produces steroid compounds which are pharmacologically valuable substances.

Process for the manufacture of 1.alpha.-hydroxydehydroepiandrosterone

The invention relates to a process for producing 7.sub..alpha. -hydroxylated steroids by fermenting or reacting a steroid to be hydroxylated with microorganisms of the genus Botryodiplodia or enzyme extracts thereof until hydroxylation occurs. The invention process produces steroid compounds which are pharmacologically valuable substances.

Process for the manufacture of hydroxylated steroids

A fermentation process for the preparation of 7.alpha.-hydroxylated steroids utilizing strains of the genus Mucor is disclosed. The 7.alpha.-hydroxylated steroids are useful intermediates for the synthesis of chenodeoxycholic acid as well as steroidal hormones.

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Yokohama, Japan

Chikara Miyamoto