Kureha Kagaku Kogyo Kabushiki Kaisha

Chikao Yoshikumi

Takayoshi Fujii

Kenichi Matsunaga

Takao Ando

Fumio Hirose

Masanori Ikuzawa

Yoshio Ohmura

Minoru Ohhara

Takao Furusho

Masahiko Fujii

Shigeaki Muto

Koichi Niimura

Toshihiko Wada

Yoshiharu Oguchi

Yuji Maeda

Tadaaki Kato

Minoru Ohara

Saburo Ueno

Hideyuki Yamato

Akihiko Kanno

Yoshio Omura

Kenichi Saito

Eiichi Takahashi

Noriyuki Toyoda

Kouichi Niimura

Yasuhiko Kobayashi

Haruhisa Hayashi

Tetsuya Hotta

Hiromitsu Makita

Kinzaburo Suzuki

Isamu Motokawa

Akira Kobayashi

Masaaki Takahashi

Satoru Enomoto

Kunitaka Hirose

Azuma Okubo

Norifumi Sugita

Junji Kakuchi

Minoru Oohara

Fumisato Yoshino

Kyoya Takahata

Yoko Onishi

Toru Hirai

Akio Shinmyo

Katsunori Miura

Sinji Nakajima

Tadao Sagi

Eiji Inoguchi

Takishi Nakanoya

Masanori Togawa

Himromitsu Makita

Mikio Matsuki

Akiyoshi Nakashima

Mayumi Nohara

Katsuo Sakurai

Tsuneo Akatsu

Shigeto Ohtsuka

Disclosed herein are polysaccharides extracted from marine algae and an antiviral drug containing as active ingredient polysaccharides extracted from seaweeds.

Polysaccharides and antiviral drugs containing the same as active

Disclosed herein is a pharmaceutical composition having antirheumatic activity, antithrombotic activity, analgetic activity, antipyretics activity, anti-hyperlipemic activity and anti-inflammatory activity and activities of reducing the level of blood sugar, raising the coronary blood flow, improving the capability of deformation of erythrocytes, reducing the blood pressure, ameliorating proteinuria and proteinemia and regulating production or metabolism of prostaglandins in a mammal in dosage unit form, which comprises a dosage effective to produce said activities of a glycoprotein having a molecular weight of 5000 to 300,000 as determined by ultracentrifugal method and about 18 to 38% by weight of proteins, produced by culturing a basidiomycetous fungal species belonging to the genus Coriolus, extracting the thus proliferated mycelia or fruit bodies with hot water or aqueous alkali solution and removing low molecular weight substances having a molecular weight of less than 5000 from the extract.

Pharmaceutical composition containing a glycoprotein

Disclosed herein is a method for preventing senescence and increasing bone mass namely, bone volume and bone strength which method comprises administering 24,25-dihydroxy cholecalciferol in a pharmaceutically effective amount, and also use of 24,25-dihydroxy cholecalciferol for preparing anti-senescent compositions and compositions for increasing bone mass.

Method for preventing senescence and increasing bone mass

Disclosed herein are lectins extracted form a plant of the class Dicotyledoneae and an antiretoviral drug comprising as an active ingredient an effective amount of the lectins.

Lectins and antiretroviral drugs containing the lectins as active

Disclosed is a pharmaceutical composition containing an aminobenzoic acid derivative as an active ingredient represented by the following general formula: ##STR1## wherein .sup.1 R donotes one member selected from the group consisting of the residual groups formed by removing OH at 1(alpha) or 1(beta) position from arabinose, glucose, galactose and mannose, or a pharmaceutically acceptable salt thereof.

Pharmaceutical compositions containing a derivative of para-aminobenzoic

Disclosed herein are an anti-tumor substance obtained by bonding an anti-tumor agent to human immunoglobulin, and a process for producing the same.

Anti-tumor substance and process for producing the same

Pharmaceutical composition containing a derivative of para-aminobenzoic

Disclosed herein is a method for inhibiting the formation of urinary calculus by the administration of 24,25-dihydroxycholecarciferol.

Method for inhibiting the formation of urinary calculus utilizing

Disclosed is nitrogen-containing polysaccharide substantially free of units having a molecular weight below about 5,000, said nitrogen-containing polysaccharide having been extracted from Coriolus versicolor (Fr.) Quel., substantially all polymer units having a molecular weight below about 5,000 having been removed therefrom, which exhibits antitumor and immunological activity.

Nitrogen-containing polysaccharide

Disclosed herein is a pharmaceutical composition having antirheumatic activity, antithrombotic activity, analgetic activity, antipyretic activity, anti-hyperlipemic activity and anti-inflammatory activity and activities of reducing the level of blood sugar, raising the coronary blood flow, improving the capability of deformation of erythrocytes, reducing the blood pressure, ameliorating proteinuria and proteinemia and regulating production or metabolism of prostaglandins in a mammal in dosage unit form, which comprises a dosage effective to produce said activities of a glycoprotein having a molecular weight of 5000 to 300000 as determined by ultracentrifugal method and about 18 to 38% by weight of proteins, produced by culturing a basidiomycetous fungal species belonging to the genus Coriolus, extracting the thus proliferated mycelia or fruit bodies with hot water or aqueous alkali solution and removing low molecular weight substances having a molecular weight of less than 5000 from the extract.

Disclosed is a pharmaceutical composition containing p-aminobenzoic acid-N-D-xyloside or a pharmaceutically a acceptable salt thereof as an active ingredient.

Pharmaceutical composition containing para-amino-benzoic

Disclosed herein is a method for examining cells, comprising subjecting the cells to an antigen-antibody reaction treatment, then measuring a pattern of the electrophoretic mobility of the cells and comparing the electrophoretic property of the cells under examination with the electrophoretic property of standard cells.

Examining cells by electrophoresis

Disclosed herein are the derivatives of substituted cephalosporanic acid represented by the formula (I): ##STR1## wherein R.sup.1 represents a 4-pyridylthiomethyl group, an alpha-aminobenzyl group, a cyanomethyl group or a 1-tetrazolylmethyl group; R.sup.2 represents a hydrogen atom, an acetoxy group or a (5-methyl-1,3,4-thiadiazol-2-yl)thio group; R.sup.3 represents a hydrogen atom, a hydroxyl group, a carbamoyl group, an alkyl group having 1 to 4 carbon atoms or --(CONH).sub.m (CH.sub.2).sub.n --COOH wherein m is 0 or 1, n is 0, 1 or 2 and the carboxyl group may have been converted to a salt or an ester thereof; p is 0, 1 or 2 and X represents carbon atom or nitrogen atom, and antibiotics comprising the derivatives of substituted cephalosporanic acid represented by the formula (I).

N-(substituted)-[7-(2-cyanoacetamido)cephalosporanic]amide derivatives

Disclosed is a method for the treatment of hyperglycemia, hyperlipemia, inflammatory diseases, pains due to the accentuation of central nerve, pyrexia due to the accentuation of central nerve or tumor, which comprises administering to a patient suffering therefrom a pharmaceutically effective amount of p-aminobenzoic acid-N-L-rhamnoside or a pharmaceutically acceptable salt thereof.

Method for the treatment of tumors

Growing community of inventors

Kunitachi, Japan

Chikao Yoshikumi