Meiji Seika Kaisha, Ltd.

Meiji Seika Pharma Co., Ltd.

Chika Kikuchi

Takashi Ando

Masao Koyama

Osamu Ushiroda

Masayo Okuno

Toyokazu Hiranuma

Tetsuya Matsushima

Kenichi Fushihara

Kenichi Kanemoto

Takehiro Yamamoto

Eriko Satoh

Kokichi Suzuki

Kazuyuki Fuji

Eriko Morita

Hiroshi Kondo

Yasuo Sato

Takeru Yamakawa

Yuji Tabata

Kou Kumura

Eijirou Umemura

Yoshinari Wakiyama

Takashi Matsuhira

Satomi Masaki

Kazutaka Ueda

Masako Imai

Hiroshi Nagaso

Naoko Watanabe

Kaori Kaneda

Yoko Hirai

Natsuki Kubota

Provided is a compound represented by formula (1a) or a pharmacologically acceptable salt thereof, which can be used as a phosphodiesterase (PDE) inhibitor. Rto Rin the formula each independently represent an alkyl group or the like. 

PDE4 inhibitor

An objective of the present invention is to provide compounds of formula (1) or their pharmacologically acceptable salts or solvates wherein A represents aryl; Rrepresents N-optionally substituted Calkyl-N-optionally substituted Calkylamino-Calkyl; Rrepresents a hydrogen atom or optionally substituted Calkyl; Rrepresents optionally substituted Calkyl or Ccycloalkyl-Calkyl; m is 1 to 3; n is 0; and p is 0 to 2. The compounds are novel lincomycin derivatives that have a potent activity against resistant, which have recently posed problems, in the treatment of infectious diseases. Further, the compounds are usable as antimicrobial agents and are useful for preventing or treating bacterial infectious diseases. 

Lincomycin derivatives and antimicrobial agents comprising the same as active ingredient

Phosphonic acid derivative having inhibitory activity against carboxypeptidase B

Phosphonic acid derivatives having carboxypeptidase b inhibitory activity

Compounds containing tetrahydrobenzindole which bind to serotonin receptor and are useful in treatment or prevention of disease induced by abnormality of central peripheral serotonin controlling functions.

Tetrahydrobenzindole derivatives

Optically active tetrahydrobenzindole type compounds having affinity for a 5-HT receptor, useful for prevention and treatment of mental diseases. A species compound is (S)-2a-4-(4-(2-methoxyphenyl)piperazinyl)butyl)-2a,3,4,5,-tetrahydro 1 H-benz&lsqb;cd&rsqb;indol-2-one.

Optically active tetrahydrobenzindole derivative

Tetrahydrobenzindole compounds

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Yokohama, Japan

Chika Kikuchi