Nippon Kayaku Kabushiki Kaisha

Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai

Chihiro Nishimura

Tomio Takeuchi

Masatoshi Abe

Tetsushi Saino

Yasuhiko Muraoka

Keiichirou Yamamoto

Masashi Nagai

Takumi Yamashita

There are disclosed a novel &#x3b1;-amino-N-(diaminophosphinyl)lactam derivative represented by general formula (1): wherein, for example, A is a hydrogen atom or a substituent such as a lower alkyl group or the like; W, X, Y and Z are independently a hydrogen atom or a substituent such as a lower alkyl group, aryl group, arylacyl group, arylaminocarbonyl group or the like; and Q is &#x2014;(CH)&#x2014; wherein n is 0 to 3, or its salt, and a therapeutic agent and a prophylactic agent for myelosuppression, a therapeutic agent for infectious diseases, an agent for increasing the number of leukocytes and a dipeptidyl peptidase IV inhibitor which comprise the above-mentioned derivative or salt thereof as an active ingredient.

&#x3b1;-Amino-N-(diaminophosphinyl)lactam derivatives

A medicament for prophylaxis or treatment of bone marrow suppression, for treatment of infectious diseases and for increasing the number of leukocytes, which comprise as an active ingredient a sulphostin-related compound represented by general formula (I): wherein n is an integer of 0 to 3, or a pharmacologically acceptable salt thereof.

Medicament for treatment of bone marrow suppression, for treatment of infectious diseases and for increasing the number of leukocytes

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Chiba, Japan

Chihiro Nishimura