Sanwa Kagaku Kenkyusho Co., Ltd.

Hirosaki University

Chihiro Hibi

Noriaki Kato

Stephen Chung

Sookja Kim Chung

Saori Ogasawara

Soroku Yagihashi

The present invention provides a protective agent for retinal nerve or optic nerve which exerts its effect through a different mechanism from that of conventional therapeutic agents and can be taken for long periods. The present invention is the protective agent for retinal nerve or optic nerve which comprises a compound with aldose reductase inhibiting activity such as the compound represented by the following general formula as an active ingredient. A preferable compound thereof is (2S,4S)-6-fluoro-2',5&#x2032;-dioxospiro[chroman-4,4&#x2032;-imidazolidine]-2-carboxamide: wherein X represents a halogen atom or a hydrogen atom, R1 and R2 independently represent a hydrogen atom or an optionally substituted C1 to C6 alkyl group, or Rand R, together with a nitrogen atom bound thereto, or optionally another nitrogen atom or an oxygen atom, are combined to form a 5- to 6-membered heterocycle.

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Nagoya, Japan

Chihiro Hibi