The Ohio State University

Chih-Ming J Chen

Sylvan G Frank

Arne F Brodin

Siriporn Panthuvanich

Ratnesh Shrivastava

The present invention is concerned with the simultaneous formation and encapsulation of small particles from aqueous solutions of compounds whose solubility is greater at a first pH than at a second pH. The process is preferably used to prepare a readily soluble encapsulated pharmaceutically active compound.

Small particule formation and encapsulation

The present invention is concerned with the simultaneous formation and encapsulation of small particles of organic compounds whose solubility in water is greater at a first pH than at a second pH by concurrently precipitating said organic compounds as small particles and forming a coacervate of an anionic (or cationic) surfactant and an amphoteric surfactant. The process is preferably used to prepare a readily soluble encapsulated pharmaceutically active compound.

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East Syracuse, NY, United States of America

Chih-Ming J Chen