Via Technologies, Inc.

Other

National Yang Ming Chiao Tung University

National Taiwan University

National Health Research Institutes

Taipei Veterans General Hospital

Tian Holdings, LLC

Tseng, Yufeng Jane

Chih-Min Liu

Chung-Ming Sun

Yufeng Jane Tseng

Yu-Li Liu

Wen-Sung Lai

Hai-Gwo Hwu

Shih-Ann Chen

Yenn-Jiang Lin

Horng-Shing Lu

Shih-Lin Chang

Hung-Hsun Chen

Wei-Shiang Chen

The present invention provides novel substituted benzimidazole derivatives used as DAAO inhibitors and for treatment and/or prevention of neurological disorders.

Substituted benzimidazole derivatives as D-amino acid oxidase (DAAO) inhibitors

The present disclosure relates to methods, apparatuses, and computer programs for processing computed tomography images. Precise segmentation of the left atrium (LA) in computed tomography (CT) images constitutes a crucial preparatory step for catheter ablation in atrial fibrillation (AF). We aim to apply deep convolutional neural networks (DCNNs) to automate the LA detection/segmentation procedure and create a three-dimensional (3D) geometries. The deep learning provides an efficient and accurate way for automatic contouring and LA volume calculation based on the construction of the 3D LA geometry. Non-pulmonary vein (NPV) trigger has been reported as an important predictor of recurrence post atrial fibrillation (AF) ablation. Elimination of NPV triggers can reduce the post-ablation AF recurrence. The deep learning was applied in pre-ablation pulmonary vein computed tomography (PVCT) geometric slices to create a prediction model for NPV triggers in patients with paroxysmal atrial fibrillation (PAF). The deep learning model using pre-ablation PVCT can be applied to predict the trigger origins in PAF patients receiving catheter ablation. The application of this model may identify patients with a high risk of NPV trigger before ablation.

Methods, apparatuses, and computer programs for processing pulmonary vein computed tomography images

The invention utilizes virtual screening strategy to seek for current market drugs as anti-schizophrenia therapy drug repurposing. Drug repurposing strategy finds new uses other than the original medical indications of existing drugs. Finding new indications for such drugs will benefit patients who are in needs for a potential new therapy sooner since known drugs are usually with acceptable safety and pharmacokinetic profiles. In this study, repurposing marketed drugs for DAAO inhibitor as new schizophrenia therapy was performed with virtual screening on marketed drugs and its metabolites. The identified and available drugs and compounds were further confirmed with in vitro DAAO enzymatic inhibitory assay.

Use of known compounds as D-amino acid oxidase inhibitors

The present invention provides novel substituted benzimidazole derivatives of formula (I) used as DAAO inhibitors and for treatment and/or prevention of neurological disorders. 

A system of sampling interface for an optical pick-up head comprises an optical pick-up head, a PMOS, a boost circuit, and a sample and hold circuit. The optical pick-up head outputs one of a reading voltage and a writing voltage. The PMOS gate receives the gate voltage and then the PMOS is turned on to pass the reading voltage to the sample and hold circuit. Moreover, the substrate of the PMOS receives a control voltage. The boost circuit is used to boost the gate voltage higher than the control voltage for turning off the PMOS and isolating the writing voltage.

System of sampling interface for an optical pick-up head

A capacitor pair structure for increasing the match thereof has two finger electrode structures interlacing with each other in parallel and a common electrode being between the two finger electrode structures to form a capacitor pair structure with an appropriate ratio. Also, the capacitor pair structure could further increase its entire capacitance through vias connecting the same capacitor pair structures on different metal layers.

Capacitor pair structure for increasing the match thereof

A transmission circuit and related method are disclosed. A transmitter in the transmission circuit has CMOS transistors as driving units for responding an input signal to drive an output signal at an output node, and each driving unit has a corresponding charge unit formed by a capacitor-connected MOS of a same type as that of the corresponding driving unit. Each charge unit is controlled by an auxiliary signal inverse to the input signal. When a level transition occurs in the input signal, the charge unit can compensate charge injection and clock feed-through caused by the driving unit at the output node, and form peaks for pre-emphasis. In this way, a better transmission property can be realized by using a simpler and low-power circuit design.

Transmission circuit and related method

A linear battery chargers is disclosed which comprises a current generator, a current detector, an operational amplifier, and a multiplexing device. The current generator provides current to charge a battery module, and the current is detected and transformed to a detected voltage by the current detector. The operational amplifier has an output terminal coupled to a control terminal of the current generator. In a constant current charge mode, the multiplexing device couples a first reference voltage and the detected voltage to first and second input terminals of the operational amplifier, respectively. The current generated by the current generator is maintained at a constant current level. In a constant voltage charge mode, the multiplexing device couples a second reference voltage and the voltage level of the battery module to the first and second input terminals of the operational amplifier, respectively. The voltage level of the battery module gradually approaches a constant voltage level.

Linear battery charger

Supply voltage level detectors are disclosed. The supply voltage level detector comprises a voltage source divider dividing a voltage source to generate a detection voltage, a bandgap reference voltage generator, a comparator comparing the detection voltage with a bandgap reference voltage generated by the bandgap reference voltage generator to determine if the voltage source is ready, a control circuit, and a forcing circuit. To ensure reliability of the comparison result, the control circuit disables the comparing device until the bandgap reference voltage is available. The forcing circuit is coupled to the output terminal of the comparing device and is controlled by the control circuit. When the comparing device is disabled, the forcing circuit forces the voltage level of the output terminal of the comparing device to a specific value indicating the voltage source is unready.

Supply voltage level detector

Transmitter and transmission circuit. For realizing a differential transmitter, a switch circuit is connected between two load transistors of two complementary MOS pairs. The switch circuit can have two inductors. When the two complementary MOS pairs are conducting current to drive signal transition at output nodes, the inductors open to make the load transistors stop draining current. Also, the switch circuit can have switch transistor controlled by an edge detector for detecting raising and falling edges of the input signals, such that the switch circuit can make the load transistors stop draining current accordingly. In this way, raising and falling edges of the output signals are emphasized to improve signal propagation.

Growing community of inventors

Taipei, Taiwan

Chih-Min Liu