Twi Biotechnology, Inc.

Industrial Technology Research Institute

Chang Gung University

Chang Gung Memorial Hospital, Linkou

Chih-Kuang Chen

Wei-Shu Lu

Carl Oscar Brown, Iii

I-Yin Lin, Iii

Jing-Yi Lee

Shih-Ming Chen

Li-Ching Wang

Mannching Sherry Ku

Po-Yuan Tseng

Jia-Chi Huang

Chen-En Tsai

Chih-Ming Chen

Hsin-Yao Wang

Young-Jen Lee

Chun-Hsien Chen

Carol Oscar Brown, Iii

Wan-Ying Lin

Yi-Ju Tseng

Kun-Tsung Lu

Jia-Chih Huang

I-Yin Lin

Carl Oscar Brown

A method for establishing a computer-aided data interpretation model for immune diseases by immunomarkers and visualization is revealed. First combine a plurality of immunomarkers into an immunomarker panel. Then collect test data of a plurality of subjects measured by the immunomarker panel, and disease diagnosis information of the subjects for establishment of an immunomarker-panel testing database. Next new subjects are tested by the immunomarker panel. The data obtained and the corresponding information in the immunomarker-panel testing database are processed by unsupervised machine learning algorithm to get a computer-aided data interpretation model showing comparison of case distribution patterns. The method provides real-time analysis of multiple data to medical professionals for their reference. Thereby the correctness, the timeliness and the reproducibility of the interpretation result for the diagnosis and treatment of immune diseases are all improved.

Method for establishing computer-aided data interpretation model for immune diseases by immunomarkers and visualization

A method for preventing or treating immunoinflammatory dermal disorders is provided. Also provided is a pharmaceutical composition for preventing or treating immunoinflammatory dermal disorders.

Methods and pharmaceutical compositions for preventing or treating immunoinflammatory dermal disorders

A topical pharmaceutical composition containing diacerein and/or its analogs is provided. Also provided is a method for treating various diseases using this topical pharmaceutical composition.

Diacerein or rhein topical formulations and uses thereof

Uses of pharmaceutical compositions comprising berberine for treatment of dermatologic toxicities and other skin disorders.

Therapeutic uses of berberine formulations

Methods and compositions for inhibiting expression of ASC, expression of NLRP3, and/or formation of NLRP3 inflammasome complex by using diacerein or its analogs are provided. Also provided are methods and compositions for the treatment and/or prevention of a disorder mediated by ASC and/or NLRP3, and/or by formation of NLRP3 inflammasome complex by using diacerein or its analogs.

Methods for inhibiting expression of ASC, expression of NLRP3, and/or formation of NLRP3 inflammasome complex using diacerein or its analogs

Diacerein or Rhein topical formulations and uses thereof

Methods and compositions for treating and/or preventing hyperuricemia or metabolic disorders associated with hyperuricemia comprising administering to a patient in need a therapeutically effective amount of diacerein, rhein, or a pharmaceutically acceptable salt, an analog, a prodrug, or an active metabolite thereof.

Methods and compositions for treating hyperuricemia and metabolic disorders associated with hyperuricemia

Methods for treating abnormal glycosylated hemoglobin (HbA1c) levels in a patient in need thereof, wherein the provided methods comprise administering to a patient in need a therapeutically effective amount of an Interleukin-1&#x3b2; modulator. Also, the invention provides compositions comprising at least one lipid modifying agent and an IL-1&#x3b2; modulator.

Methods of decreasing glycosylated hemoglobin in patients with dyslipidemia

The invention provides a method for forming optical compensating films, including: (a) providing a suspension containing clay; (b) adding a mono-functional acrylic oligomer of formula (I) in the suspension, wherein nis 2-25, Ris Calkyl or H and Ris H or CH; (c) adding a water-soluble polymer in the suspension; (d) adding a bi-functional acrylic oligomer of formula (II) in the suspension, wherein nis 3-50, and Rand Rindependently are H or CH; (e) after the step (d), drying the suspension to form a film; (f) exposing the film under UV light to cure the film; and (g) stretching the film, wherein the film has only a negative C-plate property before the stretching and has both negative C-plate and positive A-plate properties after the stretching.

Method for forming optical compensating films, optical compensating films formed thereby, structure of optical compensating films, and polarizing plates

A transparent flexible film is provided, formed by curing a composition, comprising: about 40-75 parts by weight of a clay; about 15-45 parts by weight of a water-soluble polymer; about 1-10 parts by weight of a mono-functional acrylic oligomer of formula (I), wherein nis an integer 2-25, Ris Calkyl or H, and Ris H or CH; and about 10-45 parts by weight of a bi-functional acrylic oligomer of formula (II), wherein nis an integer 3-50, Rand Rare H or CH.

Transparent flexible film and fabrication method thereof

The invention provides an antiglare film. A resin layer is disposed on a substrate. Micro-aggregates are distributed in an interior and over a surface of the resin layer. Each of the micro aggregates has a size of 0.1-3 &#x3bc;m and is formed by aggregating aggregated nano-particles. The micro-aggregates distributing over the surface result in a surface roughness of the resin layer. The weight ratio of the resin layer to the micro-aggregates is 1:0.1-0.7.

Growing community of inventors

Taipei, Taiwan

Chih-Kuang Chen