Google Inc.

National Taiwan University

National Chung Hsing University

Chih-Jen Lin

Shinn-Chih Wu

Yu-Sheng Lin

Chuan-Mu Chen

Winston T K Cheng

Jih-Tay Hsu

Cho-Jui Hsieh

Michael Ringgaard

Teng-Kuei Winston Cheng

Chi-Chen Hsu

Kuo-Joan Cheng

Yin-Wen Chang

Shwu-Wha Lin

Kai-Wei Chang

Chih-Hong Wang

Methods, systems, and apparatus, including computer programs encoded on computer storage media, for polynomial mapping of data for linear SVMs. In one aspect, a method includes training a linear classifier by receiving feature vectors and generating a condensed representation of a mapped vector corresponding to a polynomial mapping of each feature vector, the condensed representation including an index into a weight vector for each non-zero component of the mapped vector. A linear classifier is trained on the condensed representations. In another aspect, a method includes receiving a feature vector, identifying non-zero components resulting from a polynomial mapping of the feature vector, and mapping the combination of one or more elements of each non-zero component to a weight in a weight vector to determine a set of weights. The feature vector is classified according to a classification score derived by summing the set of weights.

Efficient polynomial mapping of data for use with linear support vector machines

The present invention relates to a novel promoter and its use in driving expression of foreign genes in transgenic animals (especially pigs). Accordingly, the present invention provides a method for producing transgenic animals harboring heterologous genes regulated by the promoter of the present invention.

Porcine pancreatic amylase gene promoter and transgenic pigs expressing heterologous digestive enzymes

Hemophilia A is one of the major inherited bleeding disorders caused by a deficiency or abnormality in coagulation factor VIII (FVIII). Hemophiliacs have been treated with whole plasma or purified FVIII concentrates. The risk of transmitting blood-borne viruses and the cost of highly purified FVIII are the major factors that restrict prophylaxis in hemophilia therapy. One of the challenges created by the biotechnology revolution is the development of methods for the economical production of highly purified proteins in large scales. The present invention provides improved mammary expression cassettes useful for the expression of genes at high levels in the milk of transgenic animals. In particular, the present invention provides recombinant signal peptide sequences derived from a-lactalbumin and aS1-casein milk genes suitable for leading protein secretion in the mammary gland. These gene cassettes are capable of delivering different transgenic constructs which result in the production of full-length or B domain-deleted therapeutic levels of biologically active human FVIII in the transgenic animals in vivo. Within the scope of the invention are also method for producing the transgenic non-human mammal, such as mouse, rat, rabbit, goat, sheep, pig and bovine species, capable of expressing human FVIII, and methods of making milk and methods of identifying protein from the transgenic milk.

Transgenic mammal secreting B-domain deleted human FVII in its milk

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Taipei, Taiwan

Chih-Jen Lin