Kaohsiung Medical University

Chang Gung University

Chang Gung University of Science and Technology

Chih-Hua Tseng

Cherng-Chyi Tzeng

Yeh-Long Chen

Tian-Lu Cheng

Ta-Chun Cheng

Kai-Wen Cheng

Wei-Fen Luo

Tsong-Long Hwang

Pei-Jung Lu

Kai-Wen Chang

The present invention provides novel pyrazolo[4,3-c]quinoline derivatives exhibiting specifically inhibition activity to microbiota &#x3b2;-glucuronidase, whereby providing potent activities to prevent chemotherapy-induced diarrhea (CID) of cancers. Therefore, the compounds of the present invention can be used as (1) chemotherapy-adjuvant to prevent chemotherapy-induced diarrhea (CID) and enhance chemotherapeutic efficiency of cancers; (2) health-food supplement to prevent the carcinogens induced colon carcinoma.

Pyrazolo[4,3-c]quinoline derivatives for inhibition of &#x3b2;-glucuronidase

Pyrazolo[4,3-C] quinoline derivatives for inhibition of &#x3b2;-glucuronidase

Disclosed herein are compounds of formula (I), and pharmaceutical compositions comprising the same. The compounds of formula (I) are neutrophilic inflammation inhibitors, thus, they are useful for treatment and/or prophylaxis of inflammatory diseases and/or disorders associated with abnormal activation of neutrophils, such as ARDS, ALI, COPD, lung fibrosis, chronic bronchitis, pulmonary emphysema, &#x3b1;-1 anti-trypsin deficiency, cystic fibrosis, idiopathic pulmonary fibrosis, liver injury, steatohepatitis, liver fibrosis, damages caused by ischemia and reperfusion, myocardial infarction, shock, stroke, and organ transplantation, ulcerative cholitis, vasculitis, SLE, sepsis, SIRS, arthritis, psoriasis, atopic dermatitis, and inflammatory skin diseases. 

Neutrophil inflammation inhibitor and uses thereof

Disclosed herein are novel imino-indeno[1,2-c]quinoline derivatives of formula (I):  Also disclosed are the preparation processes of these derivatives, their synthetic precursors and their uses in the manufacture of pharmaceutical compositions for use in the treatment of cancers.

Imino-indeno[1,2-c] quinoline derivatives, their preparation processes, and pharmaceutical compositions comprising the same

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Kaohsiung, Taiwan

Chih-Hua Tseng