University of Tennessee Research Foundation

Gtx Corporation

The Ohio State University

Oncternal Therapeutics, Inc.

Xomics Biopharma, Inc.

Chien-Ming Li

Duane Douglas Miller

James T Dalton

Wei Li

Jianjun Chen

Sunjoo Ahn

Yan Lu

Zhao Wang

Charles B Duke

Yong Huang

Dominique Bridon

Xuexiang Zhang

Dominique P Bridon

Li Wei

Methods for reducing platinum drug-induced toxicity in a cell expressing Organic Cation Transporter 2 (OCT2), methods for reducing platinum drug-induced toxicity in a subject, methods for treating cancer, methods for increasing efficacy of platinum drug treatment in a subject, and pharmaceutical compositions are described. The described methods and compositions include an OCT2 inhibitor where the OCT2 inhibitor is buflomedil or a salt thereof, dolutegravir or a salt thereof contains an imidazole, or is miconazole or a salt thereof.

Methods of preventing toxicity of platinum drugs

The present invention relates to a compound of formula XXII and a compound of formula 17ya, which are defined as anywhere in the specification, to a composition comprising the same, and to a method of using thereof in the treatment of various forms of cancer.

Compounds for treatment of cancer

The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and drug-resistant tumors, e.g. melanoma, metastatic melanoma, drug resistant melanoma, prostate cancer and drug resistant prostate cancer.

Compounds according to formula (I) are disclosed where Q is S, N, or O; X is optional, and can be O&#x2550;, S&#x2550;, &#x2550;N&#x2014;NH, &#x2550;N&#x2014;OH, or &#x2014;OH; Y is optional and can be &#x2014;N(H)&#x2014;, O, or Cto Chydrocarbon; and Rand Rare each independently substituted or unsubstituted single-, fused- or multiple-ring aryl or (hetero)cyclic ring systems. Methods of making these compounds, pharmaceutical compositions containing the compounds, and their use, particularly for treating or preventing cancer, are also disclosed.

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Fremont, CA, United States of America

Chien-Ming Li