Gilead Sciences, Inc.

Gilead Pharmasset LLC

Chien-Hung Chou

John O Link

Scott D Schroeder

James G Taylor

Richard L Mackman

William John Watkins

Gary Bruce Phillips

Thorsten A Kirschberg

Winston C Tse

Nathan E Wright

Musong Kim

Jeromy J Cottell

Jennifer R Zhang

Elizabeth M Bacon

Sheila M Zipfel

Qi Liu

Christopher T Clark

Randall Halcomb

Carina E Cannizzaro

Choung U Kim

Michael Graupe

Hyung-Jung Pyun

Manoj C Desai

Chandrasekar Venkataramani

Aesop Cho

Scott E Lazerwith

Zheng-Yu Yang

Michael L Mitchell

Lianhong Xu

Darryl Kato

Barton W Phillips

Eda Y Canales

Jay P Parrish

Michael O'Neil Hanrahan Clarke

Hongyan Guo

Gediminas J Brizgys

Haolun Jin

Randall W Vivian

Samuel E Metobo

Ryan McFadden

Neil H Squires

Gayatri Balan

Steven S Bondy

Kirk L Stevens

Yunfeng Eric Hu

Roland D Saito

Randall L Halcomb

Michael R Mish

Evan S Krygowski

Terry Kellar

Yafan Lu

James D Trenkle

Joseph H Saugier

John R Somoza

Qui Liu

James Taylor

Richard Mackman

Hongtao Liu

Gary Phillips

Thorstens A Kirschberg

Jianyu Sun

Neil Squires

Hongtae Liu

Xiaoning Sheng

Clarke; Michael O'Neil Hanrahan Hanrahan

Saugier; Joseph H H

Schroeder; Scott D D

Chuong U Kim

Michael O'neil Clarke

Ryan Mcfadden

The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

Cot modulators and methods of use thereof

The invention provides compounds of formula (I): or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula (I), processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus. 

Compounds for the treatment of HIV

COT modulators and methods of use thereof

Compounds of Formula I, or salts thereof, are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, intermediates useful for preparing compounds of Formula I and therapeutic, methods for treating a Retroviridae viral infection, in particular infection caused by the HIV virus. 

Therapeutic compounds

Compounds of formula (I) or salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus. 

Compounds of formula I: or salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus.

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Dublin, CA, United States of America

Chien-Hung Chou